What do systematic reviews say?

FIBRINOGEN: Prophylactic trials: intervention vs haemostatically active control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

FIBRINOGEN: Prophylactic trials: intervention vs haemostatically active control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

FIBRINOGEN: Prophylactic trials: intervention vs haemostatically active control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

FIBRINOGEN: Prophylactic trials: intervention vs inactive control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 122 participants
  Low

FIBRINOGEN: Prophylactic trials: intervention vs inactive control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 80 participants
  Moderate

Prophylactic antibiotic at one dose or duration vs Same antibiotic at a different dose or duration

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 months
  No conclusive information can be derived from the only trial that compared three different durations of antibiotic prophylaxis, since no event (implant or prosthesis failures, infections or adverse events) occurred in…
  1 study · 100 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 0.44 [0.19, 1.00]
  5 studies · 1107 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 0.69 [0.36, 1.35]
  6 studies · 1162 participants
  GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  4 months
  RR 0.33 [0.16, 0.67]
  6 studies · 1162 participants
  Moderate

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

• Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes

  3 to 5 months
  RR 1.0 [0.06, 15.85]
  6 studies · 1162 participants
  GRADE not reported

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Intensification of prophylactic therapy guided by colonoscopy showed no clear difference in clinical recurrence ( compared with intensification guided by clinical recurrence (low certainty).

• Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
  RR 0.82 [0.56, 1.18]
  1 study · 174 participants
  Low

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Intensification of prophylactic therapy guided by colonoscopy may leads to lower endoscopic recurrence ( compared with intensification guided by clinical recurrence (low certainty).

• Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
  RR 0.73 [0.56, 0.95]
  1 study · 174 participants
  Low

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

• Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  504 participants
  Very low

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

• Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 174 participants
  GRADE not reported

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

The review found no eligible studies for this question.

• Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

It is very uncertain whether intensification of prophylactic therapy guided by colonoscopy changes adverse effects ( compared with intensification guided by clinical recurrence (very low certainty).

• Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
  RR 0.78 [0.49, 1.25]
  1 study · 174 participants
  Very low

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

It is very uncertain whether prophylactic oxytocin injection (delivered by community health… changes severe postpartum haemorrhage (> 1000 mL) [ compared with control (no injection) (very low certainty).

• Oxytocin for preventing postpartum haemorrhage (PPH) in non‐facility birth settings 2016 · Cochrane Headline outcomes only
  RR 0.16 [0.02, 1.3]
  1 study · 1569 participants
  Very low

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

• Oxytocin for preventing postpartum haemorrhage (PPH) in non‐facility birth settings 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1586 participants
  Very low

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

• Oxytocin for preventing postpartum haemorrhage (PPH) in non‐facility birth settings 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1586 participants
  Very low

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Prophylactic oxytocin injection (delivered by community health… may leads to lower postpartum haemorrhage (PPH greater or equal to 500 mL) [ compared with control (no injection) (low certainty).

• Oxytocin for preventing postpartum haemorrhage (PPH) in non‐facility birth settings 2016 · Cochrane Headline outcomes only
  RR 0.48 [0.28, 0.81]
  1 study · 1574 participants
  Low
• Oxytocin for preventing postpartum haemorrhage (PPH) in non‐facility birth settings 2016 · Cochrane Headline outcomes only
  RR 0.49 [0.27, 0.9]
  1 study · 1574 participants
  Low