Modafinil vs placebo
Fatigue · people with ALS/MND
1 finding from 1 review
- Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 32 participantsVery low
Findings
What do systematic reviews say?
461 questions · 472 findings · 42 reviews · Neuromuscular
No studies found 93 · 19.7%GRADE not reported 81 · 17.2%Very low 99 · 21%Low 103 · 21.8%Moderate 75 · 15.9%High 21 · 4.4%
Modafinil vs placebo
Adverse events · people with ALS/MND
1 finding from 1 review
- Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 32 participantsVery low
Acupuncture vs placebo or sham acupuncture
Overall clinical improvement at short‐term · carpal tunnel syndrome
2 findings from 1 review
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 111 participantsVery low
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 41 participantsLow
Acupuncture vs placebo or sham acupuncture
Overall clinical improvement (at long‐term · carpal tunnel syndrome
The review found no eligible studies for this question.
1 finding from 1 review
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Acupuncture vs placebo or sham acupuncture
Adverse events · carpal tunnel syndrome
Acupuncture showed no clear difference in adverse events compared with placebo/sham acupuncture (low certainty).
1 finding from 1 review
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyRR 2.86 [0.12, 66.44]1 study · 41 participantsLow
Laser acupuncture vs placebo/sham laser acupuncture
Overall clinical improvement at short‐term · carpal tunnel syndrome
Laser acupuncture may leads to higher overall clinical improvement at short‐term compared with placebo/sham laser acupuncture (low certainty).
2 findings from 1 review
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyRR 1.59 [1.14, 2.22]1 study · 60 participantsLow
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 60 participantsLow
Laser acupuncture vs placebo/sham laser acupuncture
Overall clinical improvement at long‐term · carpal tunnel syndrome
The review found no eligible studies for this question.
1 finding from 1 review
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Laser acupuncture vs placebo/sham laser acupuncture
Adverse events (serious) · carpal tunnel syndrome
1 finding from 1 review
- Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedModerate
Methotrexate vs placebo
Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP
Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).
1 finding from 1 review
- Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes onlyRR 1.21 [0.4, 3.7]1 study · 59 participantsModerate
Methotrexate vs placebo
Change in disability after 26 or more weeks Overall Neuropathy Limitation Scale. Scale from: 0 to 12. · people with CIDP
1 finding from 1 review
- Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes onlyno estimate extracted1 study · 59 participantsLow
Methotrexate vs placebo
Change in disability after 26 or more weeks Amsterdam Linear Disability Scale. Scale from: 0 to 100. · people with CIDP
1 finding from 1 review
- Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes onlyno estimate extracted1 study · 59 participantsLow
Methotrexate vs placebo
Serious adverse events · people with CIDP
Methotrexate showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes onlyRR 3.56 [0.39, 32.23]1 study · 59 participantsModerate
Interferon beta‐1a vs placebo
Change in disability after 26 or more weeks · people with CIDP
The review found no eligible studies for this question.
1 finding from 1 review
- Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Interferon beta‐1a vs placebo
Participants who completed the study and did not restart IVIg therapy after IVIg withdrawal · people with CIDP
Interferon beta‐1a showed no clear difference in participants who completed the study and did not restart IVIg… compared with placebo (moderate certainty).
1 finding from 1 review
- Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes onlyRR 1 [0.54, 1.88]1 study · 49 participantsModerate
Interferon beta‐1a vs placebo
Serious adverse events · people with CIDP
Interferon beta‐1a showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
- Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes onlyRR 4.5 [0.25, 80.05]1 study · 67 participantsLow
Tramadol vs placebo
At least 30% reduction in pain · adults with neuropathic pain
1 finding from 1 review
- no estimate extracted2 studies · 157 participantsLow
Tramadol vs placebo
At least 50% reduction in pain · adults with neuropathic pain
Tramadol may leads to higher at least 50% reduction in pain compared with placebo (low certainty).
1 finding from 1 review
- RR 2.2 [1.02, 4.6]3 studies · 265 participantsLow
Tramadol vs placebo
Patient Global Impression of Change much or very much improved · adults with neuropathic pain
1 finding from 1 review
- no estimate extracted1 study · 35 participantsVery low
Tramadol vs placebo
Withdrawals due to adverse events · adults with neuropathic pain
Tramadol may leads to higher withdrawal due to adverse event compared with placebo (low certainty).
1 finding from 1 review
- RR 4.1 [2, 8.4]6 studies · 485 participantsLow
Tramadol vs placebo
Number experiencing adverse effects · adults with neuropathic pain
Tramadol may leads to higher participants experiencing any adverse event compared with placebo (low certainty).
1 finding from 1 review
- RR 1.6 [1.2, 2.1]4 studies · 266 participantsLow