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What do systematic reviews say?

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Evidence found and GRADE certainty

480 questions · 484 findings · 52 reviews · Musculoskeletal

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No studies found 114 · 23.6%GRADE not reported 24 · 5%Very low 33 · 6.8%Low 145 · 30%Moderate 116 · 24%High 52 · 10.7%

Tramadol vs placebo

Physical function · Patients with osteoarthritis of the knee or hip
1 finding from 1 review

Tramadol vs placebo

Number experiencing adverse effects · Patients with osteoarthritis of the knee or hip

Tramadol alone probably leads to higher number of participants experiencing any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone probably leads to higher number of participants who withdrew due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol vs placebo

Number of participants experiencing any serious adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Disease response · psoriatic arthritis

Methotrexate may leads to higher disease response compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Health‐related quality of life ‐ not reported · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Change in radiographic progression ‐ not measured · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review