Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,103 questions · 1,157 findings · 177 reviews · Headline outcomes only

No studies found 291 · 25.2%GRADE not reported 85 · 7.3%Very low 317 · 27.4%Low 258 · 22.3%Moderate 169 · 14.6%High 37 · 3.2%

Platinum doublet vs non‐platinum therapy

Toxicity – neutropenia grade 3–5 · people with advanced non‐small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status

Platinum doublet may leads to higher toxicity – neutropenia grade 3–5 compared with non‐platinum therapy (low certainty).

1 finding from 1 review

Platinum doublet vs non‐platinum therapy

Toxicity – thrombocytopenia grade 3–5 · people with advanced non‐small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status

Platinum doublet may leads to higher toxicity – thrombocytopenia grade 3–5 compared with non‐platinum therapy (low certainty).

1 finding from 1 review

Single foetal haemoglobin inducer at any dose or duration vs another dose or dose regimen of the same foetal haemoglobin inducer

Neutropenia · people with non‐transfusion‐dependent β‐thalassaemia

It is very uncertain whether one dose or dose regimen of a foetal haemoglobin inducer changes neutropenia (WBC < 1 × 103/μL, ANC < 0.5 × 103/μL) compared with another dose or dose regimen of the same foetal haemoglobin inducer (very low certainty).

1 finding from 1 review

Single foetal haemoglobin inducer at any dose or duration vs another dose or dose regimen of the same foetal haemoglobin inducer

Thrombocytopenia (platelet count < 50 × 103/μL) · people with non‐transfusion‐dependent β‐thalassaemia

It is very uncertain whether one dose or dose regimen of a foetal haemoglobin inducer changes thrombocytopenia (platelet count < 50 × 103/μL) compared with another dose or dose regimen of the same foetal haemoglobin inducer (very low certainty).

1 finding from 1 review

Laser therapy plus other treatment vs other treatment

Scar severity ‐ Helium‐Neon (He‐Ne) laser plus decamethyltetrasiloxane, polydimethylsiloxane and cyclopentasiloxane cream versus decamethyltetrasiloxane, polydimethylsiloxane and cyclopentasiloxane cream ‐ Vancouver Scar scale (VSS) (higher scores... · participants with hypertrophic and keloid scars
1 finding from 1 review

Weekly paclitaxel plus carboplatin vs tri‐weekly paclitaxel plus carboplatin

Grade 3 to 4 neutropenia · first‐line treatment of ovarian cancer

Weekly paclitaxel plus carboplatin showed no clear difference in haematological adverse event: Grade 3/4 neutropenia compared with tri‐weekly paclitaxel plus carboplatin (moderate certainty).

1 finding from 1 review

Intervention not reported

Letter with fixed appointment versus letter with open invitation to make appointment: uptake of screening · women for cervical screening

The intervention probably leads to higher letter with fixed appointment versus letter with open invitation to… (moderate certainty).

1 finding from 1 review