Findings

What do systematic reviews say?

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

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No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intervention not reported

Methylprednisolone (0 RCTs; 0 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Promethazine (0 RCTs; 0 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Total studies: 61 RCTs Total participants: 19,423 Number of treatments: 27 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
61 studies · 19423 participants
GRADE not reported

Intervention not reported

Metoclopramide (3 RCTs; 853 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 853 participants
Low

Intervention not reported

Dexamethasone (6 RCTs; 1152 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1152 participants
Low

Intervention not reported

Methylprednisolone (0 RCTs; 0 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Promethazine (0 RCTs; 0 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Total studies: 208 RCTs Total participants: 42,445 Number of treatments: 53 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
208 studies · 42445 participants
GRADE not reported

Intervention not reported

Metoclopramide (11 RCTs; 1313 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…

1 finding from 1 review

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1313 participants
Very low

Intervention not reported

Recurrence of liver metastases Number of participants developing recurrences of liver metastases · people with liver metastases

The intervention showed no clear difference in recurrence of liver metastases Number of participants developing… (low certainty).

1 finding from 1 review

Cryotherapy for liver metastases 2019 · Cochrane Headline outcomes only
RR 0.9 [0.8, 1.01]
1 study · 123 participants
Low

Intervention not reported

Time to progression of liver metastases · people with liver metastases

The review found no eligible studies for this question.

1 finding from 1 review

Cryotherapy for liver metastases 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Grommets vs active monitoring

Proportion of patients who have no AOM recurrences at 6 months post‐randomisation

Grommets may leads to higher proportion of patients who have no AOM recurrences at 6 months… compared with active monitoring (low certainty).

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
RR 9.49 [2.38, 37.8]
1 study · 95 participants
Low

Grommets vs placebo medication

Persistent tympanic membrane perforation

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 76 participants
Low

Grommets vs placebo medication

Total number of AOM recurrences at 6 months post‐randomisation

It is very uncertain whether grommets changes total number of AOM recurrences at 6 months post‐randomisation compared with placebo medication (very low certainty).

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Very low

Grommets vs active monitoring

Persistent tympanic membrane perforation

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 54 participants
Low

Grommets vs active monitoring

Proportion of patients who have no AOM recurrences at 12 months post‐randomisation

Grommets showed no clear difference in proportion of patients who have no AOM recurrences at 12 months… compared with active monitoring (low certainty).

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
RR 1.41 [1, 1.99]
1 study · 200 participants
Low

Grommets vs active monitoring

Total number of AOM recurrences at 6 months post‐randomisation

Grommets showed no clear difference in total number of AOM recurrences at 6 months post‐randomisation compared with active monitoring (low certainty).

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 95 participants
Low

Grommets vs active monitoring

Total number of AOM recurrences at 12 months post‐randomisation

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 200 participants
Low

Grommets vs active monitoring

Disease‐specific quality of life

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 85 participants
Low

Grommets vs antibiotic prophylaxis

Proportion of patients who have no AOM recurrences at 6 months post‐randomisation

It is very uncertain whether grommets changes proportion of patients who have no AOM recurrences at 6 months… compared with antibiotic prophylaxis (very low certainty).

1 finding from 1 review

Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
RR 1.68 [1.07, 2.65]
2 studies · 96 participants
Very low