Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

375 questions · 390 findings · 22 reviews · Pain, Palliative and Supportive Care

No studies found 117 · 30%GRADE not reported 36 · 9.2%Very low 111 · 28.5%Low 75 · 19.2%Moderate 48 · 12.3%High 3 · 0.8%

Application of heat vs application of cold

At least a clinically significant reduction in pain within 6 hours Reported in studies as: clinically improved or reduced pain,a or cessation of pain at end of treatmentb · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes at least a clinically significant reduction in pain within 6 hours… compared with application of cold (very low certainty).

1 finding from 1 review

Intervention not reported

Clinically significant reduction in pain · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cessation of pain at end of treatmenta · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…
1 finding from 1 review

Intervention not reported

Retreatment with the same intervention at 0 to 1 hour · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Retreatment with the alternative intervention at 0 to 1 hour · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Dermatological signs up to 1 week after the sting · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…

The review found no eligible studies for this question.

1 finding from 1 review

Application of heat vs application of cold

Adverse events due to treatment Minor adverse events, reported in studies as: exacerbation in pain after treatment; burn as a result of hot‐water immersion, or transient erythema, or adverse effects due to application of ice · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes adverse events due to treatment Minor adverse events, reported in… compared with application of cold (very low certainty).

1 finding from 1 review

Application of heat vs application of cold

Clinically significant reduction in pain · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes clinically significant reduction in pain at 0 to 1 hour Reported in… compared with application of cold (very low certainty).

1 finding from 1 review

Application of heat vs application of cold

Cessation of pain at end of treatmenta · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes cessation of pain at end of treatmentb compared with application of cold (very low certainty).

1 finding from 1 review

Application of heat vs application of cold

Retreatment with the same intervention · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes retreatment with the same intervention compared with application of cold (very low certainty).

1 finding from 1 review

Application of heat vs application of cold

Retreatment with the alternative treatment (heat or cold application) at 0 to 1 hour · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes retreatment with the alternative treatment (heat or cold… compared with application of cold (very low certainty).

1 finding from 1 review

Application of heat vs application of cold

Dermatological signs up to 1 week after the sting · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes dermatological signs up to 1 week after the sting Reported in… compared with application of cold (very low certainty).

1 finding from 1 review

Intervention not reported

At least a clinically significant reduction in pain within 6 hours Reported in study as complete cessation of pain.a · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…
1 finding from 1 review

Intervention not reported

Adverse events due to treatment · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…
1 finding from 1 review

Active stimulation vs Placebo (sham/placebo device)

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse event: lead failure/ displacement · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Participant‐reported pain relief of 50% or greater · adults with chronic pain

It is very uncertain whether active stimulation + other intervention changes pain intensity. Proportion with ≥ 50% pain relief. compared with other intervention alone (very low certainty).

1 finding from 1 review