Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 11,779 findings · 747 reviews · Headline outcomes only

No studies found 3,205 · 27.2%GRADE not reported 628 · 5.3%Very low 3,261 · 27.7%Low 2,913 · 24.7%Moderate 1,453 · 12.3%High 319 · 2.7%

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Multi‐domain interventions vs placebo or usual care

Cognitive decline · Older people living in the community
3 findings from 1 review

Lipopeptide antibiotic (daptomycin) vs aminoglycoside (low‐dose gentamicin) plus anti‐staphylococcal penicillin (nafcillin, oxacillin or flucloxacillin) or glycopeptide antibiotic (vancomycin)

Need for cardiac surgical interventions · people with endocarditis caused by Staphylococcus aureus

The review found no eligible studies for this question.

1 finding from 1 review

Glycopeptide (vancomycin or teicoplanin) plus aminoglycoside (gentamicin) vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Need for cardiac surgical interventions · people with endocarditis due to Staphylococcus aureus in drug abusers

The review found no eligible studies for this question.

1 finding from 1 review

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Need for cardiac surgical interventions · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes need for cardiac surgical interventions compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

Fosfomycin plus imipenem vs vancomycin

Need for cardiac surgical interventions · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes need for cardiac surgical interventions compared with vancomycin (very low certainty).

1 finding from 1 review