Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Lesinurad 200 mg plus allopurinol vs placebo plus allopurinol

Proportion with complete resolution of a target tophus · participants with tophi in gout

Lesinurad 200 mg plus allopurinol showed no clear difference in proportion with complete resolution of a target tophus compared with placebo plus allopurinol (moderate certainty).

1 finding from 1 review

Lesinurad 400 mg plus allopurinol vs placebo plus allopurinol

Proportion with complete resolution of a target tophus · participants with tophi in gout

Lesinurad 400 mg plus allopurinol showed no clear difference in proportion with complete resolution of a target tophus compared with placebo plus allopurinol (moderate certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing quinolone

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes clinical cure according to criteria established by authors… compared with regimens containing quinolone (very low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing quinolone

Clinical cure according to criteria established by study authors Severe PID · women with PID

Regimens containing clindamycin plus aminoglycoside showed no clear difference in clinical cure according to criteria established by authors Severe PID compared with regimens containing quinolone (low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing quinolone

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing quinolone (very low certainty).

1 finding from 1 review