Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

655 questions · 682 findings · 102 reviews

No studies found 129 · 18.9%GRADE not reported 103 · 15.1%Very low 220 · 32.3%Low 142 · 20.8%Moderate 64 · 9.4%High 24 · 3.5%

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

'Poor outcome' (dead or moved to higher level of care or unable to walk) · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes 'Poor outcome' (dead or moved to higher level of care or unable to… compared with usual care: mainly (very low certainty).

1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

Mortality (at 4 months) · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes mortality (at 4 months) compared with usual care: mainly (very low certainty).

1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

Death by the end of scheduled · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes mortality (end of scheduled compared with usual care: mainly (very low certainty).

1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

Independent in personal activities of daily living · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes independent in personal activities of daily living compared with usual care: mainly (very low certainty).

1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

Unable to walk · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes unable to walk compared with usual care: mainly (very low certainty).

1 finding from 1 review

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Ulcer healing · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Individualised homeopathic medicine (two doses over 24 hours) led to higher complete ulcer healing by end of study (day 6) compared with placebo; GRADE not reported.

1 finding from 1 review

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Mean pain score and mean ulcer size · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Pain free by end of study (day 6) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Individualised homeopathic medicine (two doses over 24 hours) led to higher pain free by end of study (day 6) compared with placebo; GRADE not reported.

1 finding from 1 review

Tooth bleaching (carbamide or hydrogen peroxide; home and/or in-office) vs No bleaching (untreated or pH-cycling control)

Caries susceptibility, enamel demineralisation, erosion, or microhardness · Permanent teeth / enamel specimens (in vitro)

Low-quality in vitro evidence suggests that bleaching of permanent teeth does not increase susceptibility to caries, demineralisation or erosion (ungraded); the clinical question could not be answered because only in vitro studies were available.

1 finding from 1 review

Tooth bleaching (carbamide or hydrogen peroxide; home and/or in-office) vs No bleaching (untreated control)

Colour change / camouflage of white spot lesions (reduction of colour disparity between carious and sound enamel) · Permanent teeth with post-orthodontic white spot lesions (orthodontic patients and in vitro enamel specimens)

Bleaching may diminish colour disparities and camouflage post-orthodontic white spot lesions, but the certainty of the evidence is very low; the findings could neither support nor refute bleaching.

1 finding from 1 review

12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel, professionally applied every 3 months plus home use vs Placebo gel

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

It is very uncertain whether 12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel,… changes number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo gel (very low certainty).

1 finding from 1 review

Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs usual care

Caries presence in primary teeth · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age

Breastfeeding promotion and support (e.g. individually tailored… showed no clear difference in caries presence in primary teeth compared with standard care (low certainty).

1 finding from 1 review

Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs usual care

Dental caries · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age

The review found no eligible studies for this question.

2 findings from 1 review

Case management for integrated care vs usual care of older people living with frailty

Change in place of residence to a nursing or residential home · people aged 65 years and older living with frailty

Case management for integrated care showed no clear difference in change in place of residence to a nursing or residential home compared with usual care of older people living with frailty (low certainty).

1 finding from 1 review

Dextrose gel vs control

Correction of hypoglycaemia for each hypoglycaemic event before discharge home (investigator defined) · newborn infants with hypoglycaemia

Oral dextrose gel showed no clear difference in correction of hypoglycaemia for each hypoglycaemic event before… compared with control (moderate certainty).

1 finding from 1 review

Dextrose gel vs control

Receipt of intravenous treatment for hypoglycaemia (yes/no) · newborn infants with hypoglycaemia

It is very uncertain whether oral dextrose gel changes receipt of intravenous treatment for hypoglycaemia before discharge… compared with control (very low certainty).

1 finding from 1 review