Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

366 questions · 703 findings · 59 reviews · All outcomes

No studies found 20 · 2.8%GRADE not reported 630 · 89.6%Very low 27 · 3.8%Low 12 · 1.7%Moderate 7 · 1%High 7 · 1%

Low-power CO2 laser irradiation (LLLT, 0.5 to 2 W) vs Placebo (placebo laser or placebo agent) or no treatment

White spot lesion incidence · High caries-risk patients: fixed-orthodontic-appliance patients and children with partially erupted permanent molars

Low-power CO2 laser (LLLT) is associated with a lower incidence of new white spot lesions than placebo (OR 0.21, CI 0.15 to 0.30; ungraded, 3 RCTs, considerable heterogeneity I2=71%).

1 finding from 1 review

Higher parental education (tertiary) vs Parental high school (secondary) education

Early childhood caries (ECC) · Healthy children under 6 years in South Africa

Parental tertiary education (vs high-school education) was associated with about 1.8 times higher odds of early childhood caries in South Africa (OR 1.77, 95% CI 1.22-2.57; 2 studies; not GRADE-rated).

1 finding from 1 review

Composite resin vs High-viscosity GIC and bulk-fill composite resins

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; tabulated failure rates ranged from 0% to 2.9%.

1 finding from 1 review

Low parental socioeconomic status (SES) vs High parental socioeconomic status (SES)

Early childhood caries (ECC) · Healthy children under 6 years in South Africa

No significant difference in caries odds was found between children of low- versus high-SES parents (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).

1 finding from 1 review

Lower parental (maternal/paternal) education vs Higher parental education

Dental caries · Healthy children and adolescents in the United Arab Emirates

The association between parental education and caries was inconsistent; father's (but not consistently mother's) education was inversely associated with caries in some studies (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Lower family socioeconomic status / income vs Higher socioeconomic position

Dental caries · Healthy children and adolescents in the United Arab Emirates

Evidence on socioeconomic status/income and caries was inconsistent: some studies linked lower income to higher caries while others found no association (narrative synthesis; not GRADE-rated).

1 finding from 1 review

AG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG vs AA model: OR 1.21, 95% CI 0.88-1.65); certainty not graded.

6 findings from 1 review
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TT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs6639060 and dental caries susceptibility (TT vs CC model: OR 1.04, 95% CI 0.43-2.51) in the Age group: Adults subgroup; certainty not graded.

3 findings from 1 review

CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT vs CC model: OR 2.80, 95% CI 0.93-8.43) in the Ethnicity: Caucasian subgroup; certainty not graded.

6 findings from 1 review
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GG genotype of LTF rs1126478 vs AA + AG genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA + AG genotype of LTF rs1126478 and dental caries susceptibility (GG vs AA + AG model: OR 0.95, 95% CI 0.80-1.13) in the Age group: Children subgroup; certainty not graded.

5 findings from 1 review
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CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The CT genotype of AMELX rs17878486 was associated with increased dental caries risk (CT vs CC model: OR 5.11, 95% CI 1.33-19.72) in the Ethnicity: Mixed subgroup; certainty not graded.

9 findings from 1 review
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GG genotype of ENAM rs3796704 vs AA + AG genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA + AG genotype of ENAM rs3796704 and dental caries susceptibility (GG vs AA + AG model: OR 1.05, 95% CI 0.66-1.68) in the Control group: Low caries subgroup; certainty not graded.

6 findings from 1 review
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CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT + TT vs CC model: OR 1.63, 95% CI 0.67-4.01) in the Ethnicity: Caucasian subgroup; certainty not graded.

6 findings from 1 review
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T allele of AMELX rs946252 vs C allele of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of AMELX rs946252 and dental caries susceptibility (T vs C model: OR 0.99, 95% CI 0.53-1.86) in the Ethnicity: Mixed subgroup; certainty not graded.

6 findings from 1 review
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