Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

572 questions · 579 findings · 55 reviews · Headline outcomes only

No studies found 60 · 10.4%GRADE not reported 42 · 7.3%Very low 205 · 35.4%Low 210 · 36.3%Moderate 52 · 9%High 10 · 1.7%

Alternative lipid emulsion (LE) vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in any BPD – OS‐LE vs S‐LE (sensitivity analysis) compared with soybean oil‐based LE (S‐LE) (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Electromagnetic‐guided vs endoscopic‐guided postpyloric placement of nasoenteral feeding tubes

Technical success in insertion

Electromagnetic‐guided showed no clear difference in technical success in insertion compared with endoscopic‐guided postpyloric placement of nasoenteral feeding tubes (low certainty).

1 finding from 1 review

Electromagnetic‐guided vs endoscopic‐guided postpyloric placement of nasoenteral feeding tubes

Aspiration pneumonitis

Electromagnetic‐guided showed no clear difference in aspiration pneumonitis compared with endoscopic‐guided postpyloric placement of nasoenteral feeding tubes (low certainty).

1 finding from 1 review

Electromagnetic‐guided vs endoscopic‐guided postpyloric placement of nasoenteral feeding tubes

Adverse events

Electromagnetic‐guided showed no clear difference in adverse events compared with endoscopic‐guided postpyloric placement of nasoenteral feeding tubes (moderate certainty).

1 finding from 1 review

Slow vs faster rates of enteral feed advancement

Necrotising enterocolitis · very preterm or very low birth weight infants

Slow showed no clear difference in necrotising enterocolitis before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow vs faster rates of enteral feed advancement

Mortality before hospital discharge · very preterm or very low birth weight infants

Slow showed no clear difference in mortality before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow vs faster rates of enteral feed advancement

Invasive infection (before hospital discharge) · very preterm or very low birth weight infants

Slow showed no clear difference in invasive infection before hospital discharge compared with faster rates of enteral feed advancement (low certainty).

1 finding from 1 review