Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

334 questions · 337 findings · 56 reviews

No studies found 77 · 22.8%GRADE not reported 5 · 1.5%Very low 113 · 33.5%Low 75 · 22.3%Moderate 61 · 18.1%High 6 · 1.8%

Intervention not reported

Endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis)

The intervention showed no clear difference in endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis) (low certainty).

1 finding from 1 review

Intervention not reported

Reduction in volume of disease, assessed endoscopically · 23 patients aged two years or older with recurrent respiratory papillomatosis
1 finding from 1 review

Intervention not reported

Gastric outlet obstruction Clinical symptoms of vomiting with confirmation of the gastric outlet obstruction by radiological or endoscopic investigations · patients with unresectable periampullary carcinoma

It is very uncertain whether the intervention changes gastric outlet obstruction Clinical symptoms of vomiting with… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐amoxiclav or cefotaxime versus placebo (percutaneous endoscopic gastrostomy) · surgical patients

It is very uncertain whether the intervention changes co‐amoxiclav or cefotaxime versus placebo (percutaneous endoscopic… (very low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Mortality ‐ within 30 days · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in mortality ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Rebleeding · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in rebleeding ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Surgery ‐ within 30 days · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in surgery ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Proportion of participants with stigmata of recent haemorrhage at index endoscopy · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in proportion of participants with stigmata of recent haemorrhage at… compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Electromagnetic‐guided vs endoscopic‐guided postpyloric placement of nasoenteral feeding tubes

Technical success in insertion

Electromagnetic‐guided showed no clear difference in technical success in insertion compared with endoscopic‐guided postpyloric placement of nasoenteral feeding tubes (low certainty).

1 finding from 1 review

Electromagnetic‐guided vs endoscopic‐guided postpyloric placement of nasoenteral feeding tubes

Aspiration pneumonitis

Electromagnetic‐guided showed no clear difference in aspiration pneumonitis compared with endoscopic‐guided postpyloric placement of nasoenteral feeding tubes (low certainty).

1 finding from 1 review

Electromagnetic‐guided vs endoscopic‐guided postpyloric placement of nasoenteral feeding tubes

Adverse events

Electromagnetic‐guided showed no clear difference in adverse events compared with endoscopic‐guided postpyloric placement of nasoenteral feeding tubes (moderate certainty).

1 finding from 1 review