Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

470 questions · 477 findings · 110 reviews · Headline outcomes only

No studies found 68 · 14.3%GRADE not reported 41 · 8.6%Very low 143 · 30%Low 133 · 27.9%Moderate 73 · 15.3%High 19 · 4%

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events the resulted in discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events the resulted in discontinuation of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events that result in the discontinuation of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria

It is very uncertain whether the intervention changes adverse events that result in the discontinuation of treatment (very low certainty).

1 finding from 1 review

Induction: liposomal amphotericin vs Amphotericin B

Safety outcomes: drug discontinuation · adults with HIV and progressive disseminated histoplasmosis

It is very uncertain whether induction: liposomal amphotericin changes safety outcomes: drug discontinuation compared with amphotericin deoxycholate (very low certainty).

1 finding from 1 review

Intervention not reported

Treatment discontinuation due to adverse event (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention probably leads to lower treatment discontinuation due to adverse event (safety population) (moderate certainty).

1 finding from 1 review

Intervention not reported

All‐cause discontinuation · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low

Intervention not reported

All‐cause discontinuation · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    17 studies · 5087 participants
    High

Bright white light therapy vs infrared light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes overall discontinuation ( compared with infrared light therapy (very low certainty).

1 finding from 1 review

Bright white light therapy vs no light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes overall discontinuation ( compared with no light therapy (very low certainty).

1 finding from 1 review

Infrared light therapy vs no light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether infrared light therapy changes overall discontinuation ( compared with no light therapy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Light therapy vs no light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether light therapy changes overall discontinuation ( compared with no light therapy (very low certainty).

1 finding from 1 review

Mindfulness‐based cognitive therapy (MBCT) vs treatment

Overall discontinuation ( · adults with a history of SAD but without depressive symptoms when treatment started

It is very uncertain whether mindfulness‐based cognitive therapy (MBCT) changes overall discontinuation rate compared with treatment (very low certainty).

1 finding from 1 review