Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

356 questions · 373 findings · 42 reviews

No studies found 47 · 12.6%GRADE not reported 21 · 5.6%Very low 68 · 18.2%Low 92 · 24.7%Moderate 97 · 26%High 48 · 12.9%

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Change in sputum P aeruginosa density at end of treatment (cfu/g) · adults and children with cystic fibrosis

Summary of findings: single showed no clear difference in change in sputum P aeruginosa density at end of treatment (cfu/g) compared with combination intravenous anti‐pseudomonal antibiotic therapy (moderate certainty).

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Need for extra treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Progression‐free survival · people with advanced gastric cancer

Taxane‐platinum‐fluoropyrimidine combinations probably leads to lower progression‐free survival compared with taxane‐platinum (without fluoropyrimidine) (moderate certainty).

1 finding from 1 review

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Treatment‐related death · people with advanced gastric cancer

It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment‐related death compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).

1 finding from 1 review

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Treatment discontinuation due to toxicity · people with advanced gastric cancer

It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment discontinuation due to toxicity compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).

1 finding from 1 review

Longer vs shorter duration of combination nicotine replacement therapy

Smoking cessation ‐ 16 weeks versus 8 weeks · people who smoke

It is very uncertain whether longer changes smoking cessation ‐ 16 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).

1 finding from 1 review

Longer vs shorter duration of combination nicotine replacement therapy

SAEs · people who smoke

It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).

3 findings from 1 review

Carboplatin vs cisplatin chemotherapy

Overall survival (baseline risks for low‐ and high‐risk groups in the control arm were estimated at 1 year) · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin showed no clear difference in overall survival (baseline risks for low‐ and high‐risk groups in… compared with cisplatin chemotherapy (high certainty).

1 finding from 1 review

Carboplatin vs cisplatin chemotherapy

Adverse events: neurotoxicity (grade 3/4) ( · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin probably leads to higher grade III or IV neurotoxicity compared with cisplatin chemotherapy (moderate certainty).

1 finding from 1 review

Carboplatin vs cisplatin chemotherapy

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin probably leads to higher grade III or IV thrombocytopenia compared with cisplatin chemotherapy (moderate certainty).

1 finding from 1 review