Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

236 questions · 244 findings · 40 reviews · Acute Respiratory Infections

No studies found 16 · 6.6%GRADE not reported 32 · 13.1%Very low 32 · 13.1%Low 60 · 24.6%Moderate 82 · 33.6%High 22 · 9%

Intervention not reported

Incidence of Pneumocystis carinii pneumonia infection in children with cancer ‐ trimethoprim‐sulfamethoxazole prophylaxis only · children with cancers aged 12 years and under

The intervention probably leads to lower incidence of Pneumocystis carinii pneumonia infection in children… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

1 finding from 1 review

Intervention not reported

Incidence of adverse events ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ co‐trimoxazole prophylaxis only (moderate certainty).

1 finding from 1 review

Intervention not reported

Incidence of Pseudomonas infection in children with cystic fibrosis ‐ ciprofloxacin prophylaxis only · children with cystic fibrosis aged 12 years and under

The intervention showed no clear difference in incidence of Pseudomonas infection in children with cystic fibrosis… (moderate certainty).

1 finding from 1 review

Intervention not reported

Treatment failure at 1 month or less · patients with acute otitis media

The intervention led to higher treatment failure at 1 month or less; GRADE not reported.

1 finding from 1 review

Intervention not reported

Treatment failure at 8 to 19 days · patients with acute otitis media

The intervention led to higher treatment failure at 8 to 19 days; GRADE not reported.

1 finding from 1 review

Intervention not reported

Treatment failure at 20 to 30 days · patients with acute otitis media

The intervention showed no clear difference in treatment failure at 20 to 30 days; GRADE not reported.

1 finding from 1 review

Intervention not reported

Treatment failure at 8 to 19 days · patients with acute otitis media

The intervention led to higher treatment failure at 8 to 19 days; GRADE not reported.

1 finding from 1 review