Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

331 questions · 361 findings · 55 reviews · Headline outcomes only

No studies found 61 · 16.9%GRADE not reported 15 · 4.2%Very low 81 · 22.4%Low 123 · 34.1%Moderate 59 · 16.3%High 22 · 6.1%

Intervention not reported

Functioningi ‐ overall analysis Using different functioning scales: FSQ (range 0 to 36), BI (range 0 to 100), AM‐PAC daily activity (range 9 to 101), COPM (range 0 to 20), LEFS (range 0 to 80), NEADL (range 0 to 66). A higher score indicates bette... · adults following hip fracture surgery

The intervention leads to higher functioningi ‐ overall analysis Using different functioning scales:… (high certainty).

1 finding from 1 review

IM erythropoietin + IV iron sucrose vs IV iron sucrose + IM placebo

Number of responders ‐ disease activity not stated (12 weeks) · IBD patients

IM erythropoietin + IV iron sucrose showed no clear difference in number of responders ‐ disease activity not stated (12 weeks) compared with IV iron sucrose + IM placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Number of participants with gadolinium‐enhancing T1 lesions on MRI · people with multiple sclerosis

It is very uncertain whether antioxidant changes MRI activity(assessed as number of participants with… compared with placebo (very low certainty).

1 finding from 1 review

Oral methotrexate and oral prednisone vs prednisone or placebo

Primary outcome: Global improvement of disease activity or damage assessed by a medical practitioner or by participants · children and adolescents with active morphea (linear scleroderma, generalised morphea and mixed subtype: linear and circumscribed).

Oral methotrexate and oral prednisone may leads to higher primary outcome: Global improvement of disease activity or damage… compared with placebo and oral prednisone (low certainty).

1 finding from 1 review

NB‐UVB vs low‐dose UVA‐1 phototherapy (20 J/cm²)

Primary outcome: Global improvement of disease activity or damage assessed by a medical practitioner or by participants · children and adults with active morphea (circumscribed morphea, linear scleroderma (with trunk/limb variant and head variant), generalised…
1 finding from 1 review

NB‐UVB vs low‐dose UVA‐1 phototherapy (20 J/cm²)

Secondary outcome: Improvement of disease activity (skin softening) · children and adults with active morphea (circumscribed morphea, linear scleroderma (with trunk/limb variant and head variant), generalised…
1 finding from 1 review