Adverse effects: dry mouth · otherwise healthy adults and children with common cold symptoms
Antihistamine‐decongestant leads to higher adverse effects: dry mouth compared with placebo (high certainty).
1 finding from 1 review
Adverse effects: insomnia · otherwise healthy adults and children with common cold symptoms
Antihistamine‐decongestant showed no clear difference in adverse effects: insomnia compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effects: gastrointestinal upset · otherwise healthy adults and children with common cold symptoms
Antihistamine‐decongestant showed no clear difference in adverse effects: gastrointestinal upset compared with placebo (moderate certainty).
1 finding from 1 review
Global evaluation · otherwise healthy adults and children with common cold symptoms
Antihistamine‐analgesic probably leads to lower global evaluation compared with placebo (moderate certainty).
1 finding from 1 review
Adverse effects: drowsiness, hypersomnia, and excessive sleepiness · otherwise healthy adults and children with common cold symptoms
Antihistamine‐analgesic showed no clear difference in adverse effects: drowsiness, hypersomnia, and excessive sleepiness compared with placebo (low certainty).
1 finding from 1 review
Global evaluation · otherwise healthy adults and children with common cold symptoms
Analgesic‐decongestant probably leads to lower global evaluation compared with placebo (moderate certainty).
1 finding from 1 review
Mortality ‐ within 30 days · people with upper gastrointestinal bleeding prior to endoscopic diagnosis
Proton pump inhibitor treatment showed no clear difference in mortality ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).
1 finding from 1 review
Rebleeding · people with upper gastrointestinal bleeding prior to endoscopic diagnosis
Proton pump inhibitor treatment showed no clear difference in rebleeding ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).
1 finding from 1 review
Surgery ‐ within 30 days · people with upper gastrointestinal bleeding prior to endoscopic diagnosis
Proton pump inhibitor treatment showed no clear difference in surgery ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).
1 finding from 1 review
Proportion of participants with stigmata of recent haemorrhage at index endoscopy · people with upper gastrointestinal bleeding prior to endoscopic diagnosis
Proton pump inhibitor treatment showed no clear difference in proportion of participants with stigmata of recent haemorrhage at… compared with H2RA, placebo or no treatment (low certainty).
1 finding from 1 review
Endoscopic haemostatic treatment at index endoscopy · people with upper gastrointestinal bleeding prior to endoscopic diagnosis
Proton pump inhibitor treatment probably leads to lower endoscopic haemostatic treatment at index endoscopy compared with H2RA, placebo or no treatment (moderate certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy
Pregabalin may leads to higher 50% or greater reduction in seizure frequency ‐ ITT analysis compared with placebo (low certainty).
3 findings from 1 review
RR 1.95 [1.4, 2.72]
9 studies · 2663 participants
Low
RR 2.91 [1.92, 4.42]
9 studies · 2663 participants
Very low
RR 1.1 [0.92, 1.31]
9 studies · 2663 participants
Very low
Adverse effects: headache · people with drug‐resistant focal epilepsy
It is very uncertain whether pregabalin changes adverse effect: headache compared with placebo (very low certainty).
1 finding from 1 review
Nausea · people with drug‐resistant focal epilepsy
Pregabalin showed no clear difference in adverse effect: nausea compared with placebo (low certainty).
1 finding from 1 review
Somnolence · people with drug‐resistant focal epilepsy
Pregabalin may leads to higher adverse effect: somnolence compared with placebo (low certainty).
1 finding from 1 review
Weight gain · people with drug‐resistant focal epilepsy
Pregabalin may leads to higher adverse effect: weight gain compared with placebo (low certainty).
1 finding from 1 review
Seizure freedom · people with drug‐resistant focal epilepsy
1 finding from 1 review
Treatment withdrawal · people with drug‐resistant focal epilepsy
Pregabalin probably leads to higher treatment withdrawal for any reason compared with placebo (moderate certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with drug‐resistant focal epilepsy
Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty).
1 finding from 1 review
Ataxia · people with drug‐resistant focal epilepsy
Pregabalin may leads to higher adverse effect: ataxia compared with placebo (low certainty).
1 finding from 1 review