Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Increment of occlusal DMFS (decayed, missing, filled surfaces) of FPMs · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

Fluoride varnish and fissure sealant did not differ significantly in occlusal DMFS increment of FPMs (MD 0.13, 95% CI -0.09 to 0.34; 3 RCTs; ungraded).

2 findings from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Asia, the pooled prevalence of primary-teeth caries in children was 52.6% (95% CI 46.7 to 58.5); certainty not graded.

1 finding from 1 review

Low maternal education (<=6 years of schooling) vs Higher maternal education (>6 years)

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Lower maternal education was associated with poor OHRQoL (OR 1.12, 95% CI 1.00-1.23; 4 studies; high heterogeneity; CI lower bound at the null; ungraded).

1 finding from 1 review

AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under a dominant model (OR 1.32, 95% CI 0.43 to 4.03; ungraded).

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Europe, the pooled prevalence of primary-teeth caries in children was 21.4% (95% CI 15.3 to 29.1); certainty not graded.

1 finding from 1 review

LTF rs6441989 variant vs Reference allele/genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

LTF rs6441989 showed no significant association with dental caries in a single study (OR 1.02, 95% CI 0.92 to 1.14; ungraded).

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

The pooled worldwide prevalence of dental caries in permanent teeth in children was 53.8% (95% CI 50.0 to 57.5), with very high heterogeneity (I2=99.8%); certainty not graded.

1 finding from 1 review