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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Dental caries

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No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Tooth bleaching (combined in-office and home bleaching) vs No bleaching (untreated control)

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Patients with post-orthodontic white spot lesions and permanent dentition

In the single RCT, all bleached patients were satisfied with the aesthetic outcome, though the trial was at high risk of bias (ungraded).

1 finding from 1 review

rs1126478, additive (per-allele) model vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The additive-model association remained non-significant after excluding the adult-data study (OR 1.47, 95% CI 0.92 to 2.35; ungraded).

2 findings from 1 review

G allele of LTF rs1126478 vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under an allelic model (OR 1.41, 95% CI 0.48 to 4.13; ungraded).

1 finding from 1 review

Bleaching vs No bleaching or alternative control

Colour disparity between carious and non-affected enamel · Permanent teeth with post-orthodontic or artificial white spot lesions

Bleaching may diminish colour disparities between carious and non-affected areas (very low certainty).

1 finding from 1 review

GG genotype of LTF rs1126478 vs GA+AA genotypes

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under a recessive model (OR 1.55, 95% CI 0.44 to 5.38; ungraded).

1 finding from 1 review

Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet

Dental caries measures other than pooled DMFT (DMFS, decayed/filled surfaces and teeth, root caries, nonvisible lesions, white spots) · General population (children and adults) assessed for dental hard-tissue health

Evidence on other dental-caries measures was inconsistent: some indices (decayed surfaces/teeth, root caries, white spots) were higher in vegetarians while some studies found lower caries in vegetarian children (ungraded).

1 finding from 1 review
  • Vegetarian diet and its possible influence on dental health: A systematic literature review. 2020 All outcomes
    Multiple countries (mostly India; also Finland and other European countries, Brazil, Trinidad and Tobago); community and clinical settings
    Eleven studies reported dental caries using 11 definitions; four (DMFT) were meta-analysed (see O2). Narrative findings were inconsistent: DMFS results were mixed; decayed surfaces and decayed teeth and percentages of…
    Studies not reported
    GRADE not reported

Bleaching gel with added remineralising agent (fluoride, calcium, or CPP-ACP) vs Bleaching alone (no remineralising agent)

Enamel resistance to demineralization (microhardness / lesion depth) · Extracted human teeth with early/artificial enamel lesions (in vitro)

Low-quality in vitro evidence suggests remineralising additives may reduce mineral loss, but no firm conclusion can be drawn.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Africa, the pooled prevalence of primary-teeth caries in children was 53.1% (95% CI 44.3 to 61.7); certainty not graded.

1 finding from 1 review