Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,747 questions · 3,943 findings · 594 reviews

No studies found 784 · 19.9%GRADE not reported 530 · 13.4%Very low 1,040 · 26.4%Low 981 · 24.9%Moderate 444 · 11.3%High 164 · 4.2%

S‐1 vs 5‐FU‐containing regimens

Treatment‐related deaths · people with advanced gastric cancer

S‐1 showed no clear difference in treatment‐related deaths compared with 5‐FU‐containing regimens (moderate certainty).

1 finding from 1 review

S‐1 vs 5‐FU‐containing regimens

Treatment discontinuation due to toxicity · people with advanced gastric cancer

S‐1 showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (high certainty).

1 finding from 1 review

Prophylactic levosimendan vs usual care

Mechanical circulatory support or cardiac transplantation · paediatric patients following heart surgery

Prophylactic levosimendan showed no clear difference in mechanical circulatory support or cardiac transplantation compared with standard treatment (low certainty).

1 finding from 1 review