S‐1 vs 5‐FU‐containing regimens
S‐1 showed no clear difference in treatment‐related deaths compared with 5‐FU‐containing regimens (moderate certainty).
- OR 0.56 [0.3, 1.06]4 studies · 1962 participantsModerate
S‐1 showed no clear difference in treatment‐related deaths compared with 5‐FU‐containing regimens (moderate certainty).
S‐1 showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (high certainty).
5‐FU/cisplatin/anthracycline combinations probably leads to lower overall survival compared with 5‐FU/cisplatin combinations (without anthracyclines) (moderate certainty).
5‐FU/cisplatin/anthracycline combinations may leads to higher tumour response compared with 5‐FU/cisplatin combinations (without anthracyclines) (low certainty).
5‐FU/cisplatin/anthracycline combinations may leads to lower time to progression compared with 5‐FU/cisplatin combinations (without anthracyclines) (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Prophylactic levosimendan showed no clear difference in mortality compared with standard treatment (low certainty).
Prophylactic levosimendan showed no clear difference in low cardiac output syndrome (LCOS) compared with standard treatment (low certainty).
Prophylactic levosimendan showed no clear difference in mechanical circulatory support or cardiac transplantation compared with standard treatment (low certainty).
It is very uncertain whether the intervention changes PTB (< 37 w) (very low certainty).
It is very uncertain whether the intervention changes LBW (< 2500 g) ‐ Treatment versus No Treatment (very low certainty).
The intervention may leads to higher NICU Admission ‐ Treatment versus No Treatment (low certainty).
The intervention may leads to higher perinatal Mortality ‐ Treatment versus No Treatment (low certainty).
It is very uncertain whether the intervention changes PTB (< 32 to 34 w) (very low certainty).