Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Radiologic relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes radiologic relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Surgical relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes surgical relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Adverse events · people with surgically‐induced remission in Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in adverse events compared with 5‐aminosalicylic acid (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Serious adverse events · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · people with surgically‐induced remission in Crohn's disease

Azathioprine or 6‐mercaptopurine may leads to higher withdrawal due to adverse events compared with 5‐aminosalicylic acid (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Clinical relapse · people with surgically‐induced remission in Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in clinical relapse compared with 5‐aminosalicylic acid (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Endoscopic relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes endoscopic relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Microbiological failure Men and women Doxycycline 100 mg twice a day for 7 days vs ofloxacin 300 mg once a day for 7 days · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…
1 finding from 1 review

Doxycycline vs quinolones

Adverse events (Analysis 1.7) Participant's report · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes adverse events Men and women Assessed by participants' self‐report compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Clinical failure Men Doxycycline 100 mg twice a day for 7 days vs ofloxacin 400 mg once a day for 7 days · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes clinical failure Men Doxycycline 100 mg twice a day for 7 days vs… compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Clinical failure Women Doxycycline 100 mg twice a day for 7 days vs ofloxacin 400 mg once a day for 7 days. · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes clinical failure Women Doxycycline 100 mg twice a day for 7 days vs… compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Microbiological failure Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes microbiological failure Men Doxycycline 100 mg twice a day for 7… compared with quinolones (very low certainty).

1 finding from 1 review

Topical ketanserin (2%) vs clioquinol cream (3%) or zinc paste

Ulcer healing · ulceration caused by nerve damage in leprosy

It is very uncertain whether topical ketanserin (2%) changes primary outcome: healing of ulcers (healing of ulcer at 3 months) compared with clioquinol cream (3%) or zinc paste (very low certainty).

1 finding from 1 review