Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population

Use of alternative/indigenous mouth-cleaning implements · Adult residents of slums and non-slum urban settings of LMICs

Indigenous/alternative cleaning tools and home remedies are widely used, more so in rural/slum groups; ungraded.

1 finding from 1 review

Cariogram multivariable caries-risk model (including modified/reduced-predictor versions) vs Alternative prediction model(s) within the same study, or no formal comparator (models compared descriptively; no between-model statistical test)

Predictive performance of the Cariogram for caries increment (positive likelihood ratio, LR+) · Children/adolescents (coronal caries) and older adults (root caries); populations from areas with varying caries risk

Modified Cariogram models showed modest positive likelihood ratios (LR+ ~1.1-3.8) for predicting caries increment, generally below the useful threshold; no pooled estimate; ungraded.

1 finding from 1 review
  • Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomes
    Follow-up >=1 year (included studies 1-5 years) · Oral health care; children/adolescents and older adults; multiple countries · Model validation studies
    Six validation studies (5 coronal, 1 root) evaluated modified Cariogram models (not the original model per se). Review-stated LR+ range 1.1-3.8 (with one exception). LR+ was not substantially changed by excluding the…
    6 studies
    GRADE not reported

Cariogram multivariable caries-risk model (including modified/reduced-predictor versions) vs Alternative prediction model(s) within the same study, or no formal comparator (models compared descriptively; no between-model statistical test)

Predictive performance of the Cariogram for caries increment (negative likelihood ratio, LR-) · Children/adolescents (coronal caries) and older adults (root caries); populations from areas with varying caries risk

Modified Cariogram models showed negative likelihood ratios of about 0.5-0.61, above the useful rule-out threshold; no pooled estimate; ungraded.

1 finding from 1 review
  • Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomes
    Follow-up >=1 year (included studies 1-5 years) · Oral health care; children/adolescents and older adults; multiple countries · Model validation studies
    Review-stated LR- range 0.5-0.61 across the Cariogram validation models (with one exception). Model performance was largely unaffected by removing the predictors mutans streptococci in saliva, saliva secretion and…
    6 studies
    GRADE not reported

Periodontal disease assessed by loss of attachment (LOA / clinical attachment loss) vs Individuals without periodontal disease (by LOA)

Oral health-related quality of life · Indian adults and elderly (general, police, teachers, institutionalised)

No difference in OHRQoL was seen between groups for periodontal disease by LOA on OHIP-14/OIDP (pooled SMD -0.04, CI includes 0); ungraded.

3 findings from 1 review

Prosthetic need vs Individuals without prosthetic need

Oral health-related quality of life · Indian elderly and general-population adults

Prosthetic need was significantly associated with poorer OHRQoL in both included studies (moderate certainty).

3 findings from 1 review

Intervention not reported

Good neurological outcome · adults after cardiopulmonary resuscitation

The intervention may leads to higher good neurological outcome (low certainty).

1 finding from 1 review

Intervention not reported

Survival · adults after cardiopulmonary resuscitation

The intervention showed no clear difference in survival (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events – pneumonia · adults after cardiopulmonary resuscitation

The intervention showed no clear difference in adverse events – pneumonia (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events – hypokalaemia · adults after cardiopulmonary resuscitation

It is very uncertain whether the intervention changes adverse events – hypokalaemia (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events – arrhythmia · adults after cardiopulmonary resuscitation

The intervention may leads to higher adverse events – arrhythmia (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Need for endotracheal tube ventilation · )

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower need for endotracheal tube ventilation compared with nasal continuous positive airway pressure (NCPAP) (by population) (moderate certainty).

1 finding from 1 review