Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,695 questions · 4,979 findings · 433 reviews

No studies found 998 · 20%GRADE not reported 1,140 · 22.9%Very low 1,024 · 20.6%Low 1,029 · 20.7%Moderate 636 · 12.8%High 152 · 3.1%

Summary of findings: feedback on medication adherence to physicians vs usual care

Health resource use Rate of hospitalisations, rate of emergency department encounters, rate of outpatient encounters, rate of oral steroid use · any physician, and any patient treated for chronic diseases with long‐term medication use
1 finding from 1 review

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Any COPD exacerbation that requires short‐burst oral corticosteroids or antibiotics, or both · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes any COPD exacerbation that requires short‐burst oral corticosteroids… compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Duodenal stenting vs surgical palliation

Re‐establishment of oral intake (technical success of the intervention) · people with malignant gastric outlet obstruction

Duodenal stenting showed no clear difference in re‐establishment of oral intake (technical success of the… compared with surgical palliation (low certainty).

1 finding from 1 review

Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method

Oral health-related quality of life · Completely edentulous people

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step elastomer (silicone, polysulfide, or polyether)… (very low certainty).

1 finding from 1 review

Routine scale and polish every 6 months vs Routine scale and polish every 12 months

Participant satisfaction (perceived oral cleanliness) · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

It is very uncertain whether routine scale and polish every 6 months changes participant satisfaction (perceived oral cleanliness) compared with routine scale and polish every 12 months (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

The review found no eligible studies for this question.

1 finding from 1 review

Routine scale and polish at a fixed interval vs No scheduled scale and polish treatment

Oral health-related quality of life · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

Planned, regular routine scale and polish (6-monthly; 12-monthly… showed no clear difference in oral health-related quality of life (OHIP-14) compared with no scheduled scale and polish treatment (high certainty).

1 finding from 1 review

Selenium vs no intervention

Quality of life and other oral related symptoms (loss of taste, dysphagia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review