Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,730 questions · 18,059 findings · 1,282 reviews

No studies found 4,360 · 24.1%GRADE not reported 2,529 · 14%Very low 4,641 · 25.7%Low 4,007 · 22.2%Moderate 2,057 · 11.4%High 465 · 2.6%

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Antibiotics vs placebo or no intervention

Cardiovascular mortality · patients with coronary heart disease

Antibiotics leads to higher cardiovascular mortality at 24±6 months compared with placebo or no intervention (high certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Myocardial infarction · patients with coronary heart disease

Antibiotics showed no clear difference in myocardial infarction at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Stroke · patients with coronary heart disease

Antibiotics showed no clear difference in stroke at 24±6 months compared with placebo or no intervention (high certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Sudden cardiac death · patients with coronary heart disease

Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Removal of short‐term indwelling urethral catheters in adults: prophylactic use of alpha blocker vs no intervention

Number of participants requiring recatheterisation · adults with short‐term indwelling urethral catheters that need to be removed

It is very uncertain whether removal of short‐term indwelling urethral catheters in adults:… changes number of participants requiring recatheterisation compared with no drug or intervention (very low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults: prophylactic use of alpha blocker vs no intervention

Symptomatic catheter associated urinary tract infection · adults with short‐term indwelling urethral catheters that need to be removed

It is very uncertain whether removal of short‐term indwelling urethral catheters in adults:… changes symptomatic catheter associated urinary tract infection compared with no drug or intervention (very low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults: prophylactic use of alpha blocker vs no intervention

Condition‐specific QoL or generic QoL measure · adults with short‐term indwelling urethral catheters that need to be removed

The review found no eligible studies for this question.

1 finding from 1 review

Recombinant human growth hormone vs placebo or no intervention

Measures of mineral metabolism: change in serum phosphate mmol/L · children with X‐linked hypophosphataemia

It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of mineral metabolism: change in serum phosphate mmol/L compared with placebo or no intervention (very low certainty).

1 finding from 1 review