Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,509 questions · 2,666 findings · 288 reviews

No studies found 743 · 27.9%GRADE not reported 327 · 12.3%Very low 775 · 29.1%Low 484 · 18.2%Moderate 279 · 10.5%High 58 · 2.2%

Doxycycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

3 findings from 1 review

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Absence (previous removal or agenesis) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth

Periodontitis (distal alveolar bone loss, adjacent second molar) · Adults (416 healthy male volunteers aged 24 to 84 years) with asymptomatic disease-free impacted wisdom teeth

It is very uncertain whether absence (previous removal or agenesis) of asymptomatic disease-free… changes periodontitis (distal alveolar bone loss, adjacent second molar) compared with presence (retention) of asymptomatic disease-free impacted wisdom… (very low certainty).

2 findings from 1 review

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Absence (previous removal or agenesis) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth

Periodontitis (distal probing depth greater than 4 mm, adjacent second molar) · Adults (416 healthy male volunteers aged 24 to 84 years) with asymptomatic disease-free impacted wisdom teeth

It is very uncertain whether absence (previous removal or agenesis) of asymptomatic disease-free… changes periodontitis (distal probing depth greater than 4 mm, adjacent… compared with presence (retention) of asymptomatic disease-free impacted wisdom… (very low certainty).

2 findings from 1 review

Metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review