Development of >=1 new carious lesion (caries incidence) · Patients with drooling (sialorrhea) due to neurological disease
In one RCT, BoNT-B 2500 U was not associated with a statistically significant increase in new caries versus placebo (RR 2.4, 95% CI 0.48 to 11.80; not significant).
2 findings from 1 review
Periodontitis (probing pocket depth) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall probably leads to higher periodontal disease: probing pocket depth (mm) compared with clinical examination with 24-month recall (moderate certainty).
1 finding from 1 review
Patient satisfaction with actual care received (1-7 scale) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall led to higher patient satisfaction with actual care received (1-7 scale) compared with clinical examination with 24-month recall; GRADE not reported.
1 finding from 1 review
Periodontitis (probing pocket depth) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall showed no clear difference in periodontal disease: probing pocket depth (mm) compared with clinical examination with 6-month recall (high certainty).
1 finding from 1 review
Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU
1 finding from 1 review
Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU
1 finding from 1 review
Dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall showed no clear difference in dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) compared with clinical examination with 6-month recall (moderate certainty).
1 finding from 1 review
Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU
Povidone iodine rinse led to lower incidence of VAP compared with saline rinse or placebo; GRADE not reported.
1 finding from 1 review
All‐cause mortality · Critically ill patients receiving mechanical ventilation in ICU
1 finding from 1 review
Povidone iodine versus usual care: single study (67 participants), no evidence of a difference in mortality.
1 study · 67 participants
GRADE not reported
Duration of mechanical ventilation · Critically ill patients receiving mechanical ventilation in ICU
Saline rinse plus swab led to lower duration of mechanical ventilation compared with saline-soaked swab alone (usual care); GRADE not reported.
1 finding from 1 review
Duration of ICU stay · Critically ill patients receiving mechanical ventilation in ICU
Povidone iodine rinse showed no clear difference in duration of ICU stay compared with saline rinse or placebo; GRADE not reported.
1 finding from 1 review
Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU
Saline rinse led to lower incidence of VAP compared with usual care (no rinse); GRADE not reported.
1 finding from 1 review
Dental caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall showed no clear difference in dental caries: number of tooth surfaces with any caries (ICDAS 1-6) compared with clinical examination with 6-month recall (high certainty).
1 finding from 1 review
Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU
1 finding from 1 review
Dental caries: prevalence of root caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall showed no clear difference in dental caries: prevalence of root caries compared with clinical examination with 24-month recall; GRADE not reported.
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · children
Age 5 years was associated with higher odds of poor OHRQoL than age older than 5 years.
1 finding from 1 review
OR 3.68 [2.20, 5.17]
1 study
GRADE not reported
Dental caries: prevalence of root caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with 24-month recall showed no clear difference in dental caries: prevalence of root caries compared with clinical examination with 6-month recall; GRADE not reported.
1 finding from 1 review
Salivary buffering capacity · Patients with drooling (sialorrhea) due to neurological disease
Salivary buffering capacity did not decrease after BoNT; one of two quasi-experimental studies reported a significant increase (ungraded; no effect estimate reported).
1 finding from 1 review
Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomesBefore vs after BoNT injection (2018 study: significant buffering increase at 1 month; 2017 study no change) · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
The quasi-experimental studies of Tiigimae-Saar found different results concerning the changes in buffering capacity. For the analysis carried out in 2017, no statistically significant change was observed. By contrast,…
2 studies
GRADE not reported
Caries increment in permanent teeth · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk)
It is very uncertain whether clinical examination with 24-month recall changes dental caries: DMFS increment (permanent teeth) compared with clinical examination with 12-month recall (very low certainty).
1 finding from 1 review
Dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall showed no clear difference in dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) compared with clinical examination with 24-month recall (moderate certainty).
1 finding from 1 review