Findings

What do systematic reviews say?

3,429 questions · 3,558 findings · 436 reviews

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No studies found 660 · 18.5%GRADE not reported 375 · 10.5%Very low 727 · 20.4%Low 887 · 24.9%Moderate 709 · 19.9%High 200 · 5.6%

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Vessel patency (up to 30 days) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Stroke · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Major bleeding · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Summary of Findings Table ‐ PBI?APBI vs WBRT

Local recurrence‐free survival · health problem or population

Summary of Findings Table ‐ PBI?APBI probably leads to higher local recurrence‐free survival ‐ total (LR‐FS) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 1.21 [1.03, 1.42]
8 studies · 13168 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Cosmesis · health problem or population

Summary of Findings Table ‐ PBI?APBI probably leads to higher cosmesis, physician/nurse‐reported compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
OR 1.57 [1.31, 1.87]
6 studies · 3652 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Overall survival · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in overall survival compared with WBRT (high certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 0.99 [0.88, 1.12]
8 studies · 13175 participants
High

Summary of Findings Table ‐ PBI?APBI vs WBRT

Late radiotherapy toxicity (subcutaneous fibrosis) · health problem or population

Summary of Findings Table ‐ PBI?APBI probably leads to higher subcutaneous fibrosis (late RT toxicity) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
OR 5.07 [3.81, 6.74]
2 studies · 3011 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Disease‐specific survival · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in cause‐specific survival (C‐SS) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 1.06 [0.83, 1.36]
7 studies · 9865 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Distant metastasis‐free survival · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in distant metastasis‐free survival (DM‐FS) compared with WBRT (moderate certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
HR 0.95 [0.8, 1.13]
7 studies · 11033 participants
Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Subsequent mastectomy · health problem or population

Summary of Findings Table ‐ PBI?APBI showed no clear difference in subsequent mastectomy compared with WBRT (high certainty).

1 finding from 1 review

Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
OR 0.98 [0.78, 1.23]
3 studies · 3740 participants
High

Summary of findings table ‐ Psychological interventions vs control

Depression symptoms ‐ short‐term · health problem or population

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1226 participants
Low

Psychological interventions vs psychological treatment

Myocardial infarction ‐ short term (end of treatment) ‐ not reported · health problem or population

The review found no eligible studies for this question.

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pharmacological treatment vs placebo

Depression symptoms ‐ short term · health problem or population

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 750 participants
Low

Pharmacological treatment vs placebo

Depression remission · health problem or population

Summary of findings table ‐ Pharmacological treatment probably leads to higher depression remission ‐ short term compared with placebo (moderate certainty).

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
OR 2.06 [1.47, 2.89]
4 studies · 646 participants
Moderate

Pharmacological treatment vs placebo

All‐cause mortality ‐ short term · health problem or population

It is very uncertain whether summary of findings table ‐ Pharmacological treatment changes all‐cause mortality ‐ short term compared with placebo (very low certainty).

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
OR 0.38 [0.1, 1.47]
2 studies · 437 participants
Very low

Pharmacological treatment vs placebo

Cardiovascular mortality · health problem or population

The review found no eligible studies for this question.

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pharmacological treatment vs placebo

Myocardial infarction (0 to 30 days) · health problem or population

It is very uncertain whether summary of findings table ‐ Pharmacological treatment changes myocardial infarction ‐ short term compared with placebo (very low certainty).

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
OR 0.74 [0.26, 2.09]
3 studies · 728 participants
Very low

Pharmacological treatment vs pharmacological treatment 2

Depression symptoms ‐ short term (end of treatment) · health problem or population

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 442 participants
GRADE not reported

Pharmacological treatment vs pharmacological treatment 2

Depression remission · health problem or population

1 finding from 1 review

Psychological and pharmacological interventions for depression in patients with coronary artery disease 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 243 participants
GRADE not reported