What do systematic reviews say?

Intervention not reported

• Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia: a network… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in cumulative live birth compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.95 [0.82, 1.1]
  4 studies · 985 participants
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.13 [0.08, 0.21]
  4 studies · 985 participants
  Moderate

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in clinical pregnancy rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.95 [0.84, 1.08]
  3 studies · 943 participants
  Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 2.14 [0.93, 4.95]
  2 studies · 282 participants
  Low

Single vs multiple embryo transfer

Single may leads to lower live birth compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.67 [0.59, 0.75]
  12 studies · 1904 participants
  Low

Single vs multiple embryo transfer

Single probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.16 [0.12, 0.22]
  13 studies · 1952 participants
  Moderate

Single vs multiple embryo transfer

Single may leads to lower clinical pregnancy compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  RR 0.7 [0.64, 0.77]
  10 studies · 1860 participants
  Low

Single vs multiple embryo transfer

Single showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

• Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
  odds ratio 0.96 [0.66, 1.42]
  7 studies · 1560 participants
  Low

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Moderate

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Moderate

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention probably leads to lower presence of PDA on third to fourth day of life (after 72 hours of… (moderate certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 0.39 [0.31, 0.48]
  9 studies · 1029 participants
  Moderate

Intervention not reported

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 827 participants
  High

Intervention not reported

The intervention probably leads to lower need for surgical closure of PDA (during hospital stay) (moderate certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 0.46 [0.22, 0.96]
  7 studies · 925 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in IVH grade III to IV (during hospital stay) (moderate certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 0.67 [0.45, 1]
  7 studies · 925 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in NEC (during hospital stay) (moderate certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 0.96 [0.61, 1.5]
  9 studies · 1028 participants
  Moderate

Intervention not reported

The intervention may leads to higher gastrointestinal haemorrhage (during hospital stay) (low certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 2.05 [1.19, 3.51]
  5 studies · 282 participants
  Low