It is very uncertain whether calcium hydroxide cement (Dycal) changes radiological failure compared with calcium sulphate hemihydrate (DentoGen) (very low certainty).
Biodentine showed no clear difference in clinical failure compared with propolis; GRADE not reported.
Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with sealapex (eugenol-free calcium hydroxide); GRADE not reported.
Zinc oxide and eugenol (ZOE) showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.
Diode laser showed no clear difference in radiological failure compared with electrosurgery (low certainty).
It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).
Sealapex (eugenol-free calcium hydroxide) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.
Beta‐blockers showed no clear difference in total mortality compared with renin‐angiotensin system inhibitors (moderate certainty).
Beta‐blockers showed no clear difference in total cardiovascular disease compared with renin‐angiotensin system inhibitors (low certainty).
Beta‐blockers probably leads to higher total stroke compared with renin‐angiotensin system inhibitors (moderate certainty).
Beta‐blockers showed no clear difference in total coronary heart disease compared with renin‐angiotensin system inhibitors (low certainty).
Beta‐blockers probably leads to higher withdrawal due to adverse effect compared with renin‐angiotensin system inhibitors (moderate certainty).
Sildenafil may leads to lower all‐cause mortality compared with placebo (low certainty).
It is very uncertain whether sildenafil changes all‐cause mortality compared with active control (very low certainty).
Sildenafil plus iNO showed no clear difference in all‐cause mortality compared with placebo plus iNO (low certainty).