What do systematic reviews say?

Intervention not reported

• Blood pressure‐lowering efficacy of loop diuretics for primary hypertension 2015 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 460 participants
  Low

Intervention not reported

• Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1007 participants
  Low

Intervention not reported

• Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1007 participants
  Low

Intervention not reported

• Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 977 participants
  Low

Intervention not reported

• Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1007 participants
  Very low

Intervention not reported

• Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1412 participants
  Moderate

Intervention not reported

• Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  188 studies · 21941 participants
  High

Intervention not reported

• Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  80 studies · 9310 participants
  High

Intervention not reported

• Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  37 studies · 3296 participants
  High

Intervention not reported

• Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  37 studies · 4281 participants
  High

Intervention not reported

• Atorvastatin for lowering lipids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  34 studies · 3688 participants
  Very low

Intervention not reported

The intervention showed no clear difference in incidence of pulmonary tuberculosis in children with HIV infection ‐… (moderate certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 0.64 [0.32, 1.29]
  2 studies · 810 participants
  Moderate

Intervention not reported

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 312 participants
  Moderate

Intervention not reported

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 106 participants
  Moderate

Intervention not reported

The intervention leads to lower episodes of pulmonary exacerbations ‐ azithromycin prophylaxis only (high certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 0.6 [0.48, 0.76]
  2 studies · 323 participants
  High

Intervention not reported

The intervention probably leads to lower incidence of Pneumocystis carinii pneumonia infection in children… (moderate certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 0.03 [0, 0.47]
  1 study · 160 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in mortality in children with HIV infection ‐ overall (moderate certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 0.82 [0.46, 1.46]
  3 studies · 1344 participants
  Moderate

Intervention not reported

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 0.67 [0.53, 0.85]
  1 study · 534 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 0.92 [0.31, 2.77]
  2 studies · 810 participants
  Low

Intervention not reported

The intervention showed no clear difference in incidence of adverse events ‐ overall (moderate certainty).

• Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
  RR 1.1 [0.75, 1.64]
  3 studies · 1344 participants
  Moderate