What do systematic reviews say?

First trimester routine vs selective ultrasound

First trimester routine probably leads to lower maternal anxiety3 compared with selective ultrasound (moderate certainty).

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  RR 0.8 [0.65, 0.99]
  1 study · 634 participants
  Moderate

Second trimester routine vs selective ultrasound

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

First trimester routine vs selective ultrasound

First trimester routine showed no clear difference in perinatal loss compared with selective ultrasound (low certainty).

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  RR 0.97 [0.55, 1.73]
  1 study · 648 participants
  Low

First trimester routine vs selective ultrasound

First trimester routine showed no clear difference in induction of labour for post‐maturity compared with selective ultrasound (low certainty).

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  RR 0.83 [0.5, 1.37]
  3 studies · 1474 participants
  Low

First trimester routine vs selective ultrasound

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

First trimester routine vs selective ultrasound

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Second trimester routine vs selective ultrasound

Second trimester routine showed no clear difference in perinatal loss compared with selective ultrasound (moderate certainty).

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  RR 0.98 [0.81, 1.2]
  3 studies · 17918 participants
  Moderate

Second trimester routine vs selective ultrasound

Second trimester routine probably leads to lower induction of labour for post‐maturity compared with selective ultrasound (moderate certainty).

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  RR 0.48 [0.31, 0.73]
  6 studies · 24174 participants
  Moderate

Second trimester routine vs selective ultrasound

Second trimester routine probably leads to higher termination of pregnancy for fetal abnormality compared with selective ultrasound (moderate certainty).

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  RR 2.36 [1.13, 4.93]
  4 studies · 26893 participants
  Moderate

Second trimester routine vs selective ultrasound

• Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Sealing using sealant materials vs Non-selective carious tissue removal and conventional restoration (CR)

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  Non-cavitated lesions, primary dentition
  Lesion progression reported narratively: Borges 2012a found 3/26 sealed lesions progressed after 1 year (split-mouth); not pooled and not GRADE-rated.
  1 study
  GRADE not reported

Sealing using sealant materials vs Non-selective carious tissue removal and conventional restoration (CR)

It is very uncertain whether sealing using sealant materials changes failure of therapy compared with non-selective carious tissue removal and conventional restoration (CR) (very low certainty).

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  48 months · Cavitated lesions, permanent dentition
  OR 5.0 [0.51, 49.27]
  1 study · 41 participants
  Very low

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

The review found no eligible studies for this question.

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in hyperkalaemia compared with selective aldosterone antagonist (low certainty).

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  RR 0.89 [0.45, 1.77]
  1 study · 1023 participants
  Low

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in death compared with selective aldosterone antagonist (low certainty).

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  RR 0.7 [0.31, 1.55]
  1 study · 1055 participants
  Low

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

The review found no eligible studies for this question.

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in doubling serum creatinine compared with selective aldosterone antagonist (low certainty).

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  RR 0.8 [0.03, 19.51]
  1 study · 1055 participants
  Low

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

The review found no eligible studies for this question.

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

The review found no eligible studies for this question.

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

The review found no eligible studies for this question.

• Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found