Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

407 questions · 412 findings · 45 reviews · Headline outcomes only

No studies found 137 · 33.3%GRADE not reported 8 · 1.9%Very low 129 · 31.3%Low 88 · 21.4%Moderate 47 · 11.4%High 3 · 0.7%

Injectional verapamil vs saline (short‐term)

Patient‐reported ability to have intercourse · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether injectional verapamil changes patient‐reported ability to have intercourse compared with saline (short‐term) (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review