Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

FIBRINOGEN: Prophylactic trials: intervention vs inactive control

Arterial thrombotic events ‐ up to 30 days post‐operatively · the prevention and treatment of bleeding in patients without haemophilia

FIBRINOGEN: Prophylactic trials: intervention showed no clear difference in arterial thrombotic events Up to 30 days post‐operatively compared with inactive control (low certainty).

2 findings from 1 review

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

Intensification of prophylactic therapy guided by colonoscopy showed no clear difference in clinical recurrence ( compared with intensification guided by clinical recurrence (low certainty).

1 finding from 1 review

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

Intensification of prophylactic therapy guided by colonoscopy may leads to lower endoscopic recurrence ( compared with intensification guided by clinical recurrence (low certainty).

1 finding from 1 review

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Adverse effects ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

It is very uncertain whether intensification of prophylactic therapy guided by colonoscopy changes adverse effects ( compared with intensification guided by clinical recurrence (very low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Severe postpartum haemorrhage · pregnant women giving birth in non‐facility settings

It is very uncertain whether prophylactic oxytocin injection (delivered by community health… changes severe postpartum haemorrhage (> 1000 mL) [ compared with control (no injection) (very low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Postpartum haemorrhage · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… may leads to lower postpartum haemorrhage (PPH greater or equal to 500 mL) [ compared with control (no injection) (low certainty).

2 findings from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Maternal transfer or referral to a health facility · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in transfer or referral to health facility [ compared with control (no injection) (low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Stillbirth · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in stillbirths [ compared with control (no injection) (low certainty).

1 finding from 1 review