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Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

185 questions · 188 findings · 18 reviews · Headline outcomes only

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No studies found 35 · 18.6%GRADE not reported 3 · 1.6%Very low 27 · 14.4%Low 63 · 33.5%Moderate 43 · 22.9%High 17 · 9%

Intervention not reported

Hair loss grade 3 or 4 (safety population) · women with metastatic breast cancer

The intervention leads to higher hair loss grade 3 or 4 (safety population) (high certainty).

1 finding from 1 review

Intervention not reported

Death from all causes · patients with early stage cervical cancer

The intervention probably leads to lower death from all causes (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease progression · patients with early stage cervical cancer

The intervention probably leads to lower disease progression (moderate certainty).

1 finding from 1 review

Intervention not reported

Grade 4 toxicity3 · patients with early stage cervical cancer

The intervention probably leads to higher grade 4 toxicity3 (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease progression · patients with early stage cervical cancer

The intervention showed no clear difference in disease progression (low certainty).

1 finding from 1 review