Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

189 questions · 192 findings · 19 reviews

No studies found 35 · 18.2%GRADE not reported 5 · 2.6%Very low 27 · 14.1%Low 64 · 33.3%Moderate 44 · 22.9%High 17 · 8.9%

Intervention not reported

Objective tumour response rate (assessable participants) ‐ trials of metastatic breast cancer participants unselected for TNBC · women with metastatic breast cancer unselected for triple‐negative breast cancer (TNBC)

The intervention may leads to higher objective tumour response rate (assessable participants) ‐ trials of… (low certainty).

1 finding from 1 review

Intervention not reported

Overall survival ‐ trials of mTNBC participants · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention showed no clear difference in overall survival ‐ trials of mTNBC participants (low certainty).

1 finding from 1 review

Intervention not reported

Progression‐free survival/time to progression (randomised participants) ‐ trials of mTNBC participants · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to lower progression‐free survival/time to progression (randomised… (low certainty).

1 finding from 1 review

Intervention not reported

Objective tumour response rate (assessable participants) ‐ trials of mTNBC participants · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to higher objective tumour response rate (assessable participants) ‐ trials of… (low certainty).

1 finding from 1 review

Intervention not reported

Hair loss grade 3 or 4 (safety population) · women with metastatic breast cancer

The intervention leads to higher hair loss grade 3 or 4 (safety population) (high certainty).

1 finding from 1 review

Intervention not reported

Death from all causes · patients with early stage cervical cancer

The intervention probably leads to lower death from all causes (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease progression · patients with early stage cervical cancer

The intervention probably leads to lower disease progression (moderate certainty).

1 finding from 1 review

Intervention not reported

Grade 4 toxicity3 · patients with early stage cervical cancer

The intervention probably leads to higher grade 4 toxicity3 (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease progression · patients with early stage cervical cancer

The intervention showed no clear difference in disease progression (low certainty).

1 finding from 1 review