Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 466 findings · 48 reviews · Schizophrenia

No studies found 87 · 18.7%GRADE not reported 82 · 17.6%Very low 153 · 32.8%Low 111 · 23.8%Moderate 19 · 4.1%High 14 · 3%

Benzodiazepines vs placebo

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether benzodiazepines changes tardive dyskinesia: no clinically important improvement compared with placebo (very low certainty).

1 finding from 1 review

Benzodiazepines vs placebo

Tardive dyskinesia: Deterioration of symptoms · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether benzodiazepines changes tardive dyskinesia: deterioration in symptoms compared with placebo (very low certainty).

1 finding from 1 review

Benzodiazepines vs placebo

Acceptability · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether benzodiazepines changes acceptability of the treatment (measured by participants leaving the… compared with placebo (very low certainty).

1 finding from 1 review

Benzodiazepines vs phenobarbital (as active placebo)

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether benzodiazepines changes tardive dyskinesia: no clinically important improvement compared with phenobarbital (as active placebo) (very low certainty).

1 finding from 1 review

CHOLINERGIC DRUGS vs placebo

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether CHOLINERGIC DRUGS changes tardive dyskinesia: No clinically important improvement compared with PLACEBO (very low certainty).

1 finding from 1 review

ALKALOID ‐ DIHYDROGENATED ERGOT ALKALOIDS vs placebo

Tardive dyskinesia: No clinically important improvement · female and male 59‐80 (mean) years old patients with antipsychotic‐induced tardive dyskinesia

ALKALOID ‐ DIHYDROGENATED ERGOT ALKALOIDS may leads to lower tardive dyskinesia: No clinically important improvement compared with PLACEBO (low certainty).

1 finding from 1 review