Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

603 questions · 627 findings · 69 reviews · Pain, Palliative and Supportive Care

No studies found 111 · 17.7%GRADE not reported 27 · 4.3%Very low 191 · 30.5%Low 138 · 22%Moderate 100 · 15.9%High 60 · 9.6%

Active stimulation vs Placebo (sham/placebo device)

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

3 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse events: infection · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

HALOPERIDOL vs placebo

Symptoms of delirium within 24 hoursa · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in symptoms of delirium within 24 hoursa compared with placebo (low certainty).

1 finding from 1 review

RISPERIDONE vs placebo

Symptoms of delirium within 24 hoursa · terminally ill adults with delirium

Summary of findings: risperidone showed no clear difference in symptoms of delirium within 24 hoursa compared with placebo (low certainty).

1 finding from 1 review

RISPERIDONE vs placebo

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

Summary of findings: risperidone showed no clear difference in symptoms of delirium between 24 and 48 hoursa compared with placebo (low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in symptoms of delirium between 24 and 48 hoursa compared with placebo (low certainty).

1 finding from 1 review

RISPERIDONE vs placebo

Adverse events including extrapyramidal effects · terminally ill adults with delirium

Summary of findings: risperidone showed no clear difference in adverse events including extrapyramidal effectsd compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Specific behaviour ‐ agitation · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes agitation within 24 hoursc compared with placebo plus haloperidol (very low certainty).

2 findings from 1 review

Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Adverse events including extrapyramidal effects · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes adverse events including extrapyramidal effectsd compared with placebo plus haloperidol (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Adverse events including extrapyramidal effects · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in adverse events including extrapyramidal effectse compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Total studies: 55* Total participants: 3758 No. interventions in network: 21 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower total studies: 55* Total participants: 3758 No. interventions in…; GRADE not reported.

1 finding from 1 review