Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

296 questions · 315 findings · 41 reviews · Neonatal

No studies found 70 · 22.2%GRADE not reported 6 · 1.9%Very low 76 · 24.1%Low 92 · 29.2%Moderate 57 · 18.1%High 14 · 4.4%

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

Any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis available] · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation with enteral feeds in combination with… may leads to lower any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis… compared with placebo (low certainty).

1 finding from 1 review

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

NEC ≥ stage II · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes NEC ≥ stage II compared with placebo (very low certainty).

1 finding from 1 review

Zinc vs placebo; no treatment

Stunted after 6 months · the promotion of growth and prevention of infections in infants less than six months of age

Zinc supplementation showed no clear difference in stunted after 6 months compared with placebo; no treatment (moderate certainty).

1 finding from 1 review

Zinc vs placebo; no treatment

Wasted after 6 months · the promotion of growth and prevention of infections in infants less than six months of age

Zinc supplementation showed no clear difference in wasted after 6 months compared with placebo; no treatment (low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Nutritional rickets ‐ radiological · term breastfed infants to prevent vitamin D deficiency and improve bone health

It is very uncertain whether vitamin D given to lactating mothers changes nutritional rickets ‐ radiological compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers showed no clear difference in adverse effects (hypercalcaemia) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to infants vs placebo or no treatment

Vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants may leads to lower vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to infants vs placebo or no treatment

Vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

It is very uncertain whether vitamin D given to infants changes vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Vitamin D given to infants vs placebo or no treatment

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants showed no clear difference in adverse effects (hypercalcaemia) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers may leads to lower vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers may leads to lower vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L compared with placebo or no treatment (low certainty).

1 finding from 1 review