Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

233 questions · 238 findings · 13 reviews · Common Mental Disorders

No studies found 56 · 23.5%GRADE not reported 7 · 2.9%Very low 84 · 35.3%Low 62 · 26.1%Moderate 22 · 9.2%High 7 · 2.9%

Antipsychotics vs placebo or another comparator drug/dose

Repetition of SH at six months (low dose fluphenazine vs. ultra low dose fluphenazine) · adults who engage in SH

It is very uncertain whether antipsychotics changes repetition of SH at six months (low dose fluphenazine vs. ultra low… compared with placebo or another comparator drug/dose (very low certainty).

1 finding from 1 review

Propranolol vs placebo

Treatment efficacy CAPS, CIDI · adult participants (18 years and older) who have been exposed to any traumatic events, but who did not meet the diagnostic criteria for…

Propranolol showed no clear difference in treatment efficacy CAPS, CIDI compared with placebo (low certainty).

1 finding from 1 review

Hydrocortisone vs placebo

Treatment efficacy CAPS, SCID‐IV, PTSS‐10Q‐I · adult participants (18 years and older) who have been exposed to any traumatic events, but who did not meet the diagnostic criteria for…

Hydrocortisone probably leads to lower treatment efficacy CAPS, SCID‐IV, PTSS‐10Q‐I compared with placebo (moderate certainty).

1 finding from 1 review

New‐generation antidepressants vs placebo

Treatment response (post‐treatment score on self report and clinician‐rated scales) · somatoform disorders in adults

It is very uncertain whether new‐generation antidepressants changes treatment response (post‐treatment score on self report and… compared with placebo (very low certainty).

1 finding from 1 review

Natural products vs placebo

Treatment response (post‐treatment score on self report and clinician‐rated scales) · somatoform disorders in adults

It is very uncertain whether natural products changes treatment response (post‐treatment score on self report and… compared with placebo (very low certainty).

1 finding from 1 review