Cochrane · systematic review · CD006239
Pharmacological interventions for preventing post‐traumatic stress disorder (PTSD)
Amos, T, Stein, DJ, Ipser, JC · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
2
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Propranolol compared to placebo for preventing post‐traumatic stress disorder (PTSD)
Population: adult participants (18 years and older) who have been exposed to any traumatic events, but who did not meet the diagnostic criteria for PTSD at study recruitment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment efficacy CAPS, CIDI Propranolol vs placebo | RR 0.62 [0.24, 1.59] | 3 studies · 118 participants | Low Downgraded: risk of bias, imprecision |
Hydrocortisone compared to placebo for preventing post‐traumatic stress disorder (PTSD)
Population: adult participants (18 years and older) who have been exposed to any traumatic events, but who did not meet the diagnostic criteria for PTSD at study recruitment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment efficacy CAPS, SCID‐IV, PTSS‐10Q‐I Hydrocortisone vs placebo | RR 0.17 [0.05, 0.56] | 4 studies · 165 participants | Moderate Downgraded: risk of bias, imprecision |