Findings

What do systematic reviews say?

280 questions · 280 findings · 13 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 127 · 45.4%GRADE not reported 3 · 1.1%Very low 85 · 30.4%Low 46 · 16.4%Moderate 19 · 6.8%High 0 · 0%

Duoderm® (hydroactive dressing) vs antiseptic agent

Adverse events · individuals with sickle cell disease and a leg ulcer

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
GRADE not reported

Isoxsuprine vs placebo

Quality of life ‐ not reported · individuals with sickle cell disease and a leg ulcer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Isoxsuprine vs placebo

Amputation ‐ not reported · individuals with sickle cell disease and a leg ulcer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Isoxsuprine vs placebo

Adverse events ‐ not reported · individuals with sickle cell disease and a leg ulcer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Arginine butyrate plus standard care alone vs usual care

Ulcer healing · individuals with sickle cell disease and a leg ulcer

It is very uncertain whether arginine butyrate plus standard care alone changes complete leg ulcer closure (defined as 100% epithelization or skin… compared with standard care alone (very low certainty).

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
RR 3.72 [0.9, 15.35]
1 study · 23 participants
Very low

Arginine butyrate plus standard care alone vs usual care

Time to ulcer closure ‐ not reported · individuals with sickle cell disease and a leg ulcer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cisapride vs placebo

Radiological diagnosis of DIOS (physician‐measured radiological scores) · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Cisapride vs placebo

Adverse effects (participant interviews) · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Cisapride vs placebo

Total gastrointestinal symptom scores (participant‐reported symptom scores from 20 to 100) · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Cisapride vs placebo

Hospitalisation (any cause) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cisapride vs placebo

Hospitalisation for DIOS · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cisapride vs placebo

Quality of life · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cisapride vs placebo

Tolerability · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Time taken from start of treatment until the resolution of DIOS · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Treatment failure rate · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Adherence · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Episodes of acute DIOS · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Adverse effects: abdominal mass · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Abdominal pain · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Mood or personal well‐being · adults and children with hemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found