Findings

What do systematic reviews say?

484 questions · 512 findings · 35 reviews · Common Mental Disorders

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No studies found 137 · 26.8%GRADE not reported 12 · 2.3%Very low 156 · 30.5%Low 136 · 26.6%Moderate 60 · 11.7%High 11 · 2.1%

Hydrocortisone vs placebo

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydrocortisone vs placebo

PTSD rate at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydrocortisone vs placebo

Functional disability at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydrocortisone vs placebo

Quality of life at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Propranolol vs placebo

Severity of PTSD symptoms ‐ Clinician‐rated · adults (aged 18 and older) exposed to a traumatic event

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 86 participants
Very low

Propranolol vs placebo

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Propranolol vs placebo

PTSD rate at 3 months · adults (aged 18 and older) exposed to a traumatic event

It is very uncertain whether propranolol changes PTSD rate at 3 months compared with placebo (very low certainty).

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
RR 0.77 [0.31, 1.92]
3 studies · 88 participants
Very low

Propranolol vs placebo

Functional disability at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Teaching Recovery Techniques vs waiting list control

PTS symptoms ‐ intermediate term (1 to 6 months post intervention) PCL‐5a,d,e; PCL‐6f; Post‐traumatic Stress Diagnostic Scaleb (higher score = higher severity) · health problem or population

1 finding from 1 review

Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 63 participants
Low

Summary of findings table ‐ Teaching Recovery Techniques vs waiting list control

Symptoms of depression at 3 months post‐treatment · health problem or population

1 finding from 1 review

Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 63 participants
Low

Summary of findings table ‐ Teaching Recovery Techniques vs waiting list control

Psychological distress post‐treatment · health problem or population

1 finding from 1 review

Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Summary of findings table ‐ Teaching Recovery Techniques vs waiting list control

Child behaviour · health problem or population

1 finding from 1 review

Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Summary of findings table ‐ Teaching Recovery Techniques vs waiting list control

Externalising behaviours 3 months post‐treatment · health problem or population

2 findings from 1 review

Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low
Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 82 participants
Low

Summary of findings table ‐ Teaching Recovery Techniques vs waiting list control

Internalising behaviours 3 months post‐treatment · health problem or population

2 findings from 1 review

Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low
Community‐based interventions for improving mental health in refugee children and adolescents in high‐income countries 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 82 participants
Low

Atypical vs Typical antipsychotics

Diabetes · Adults with mental disorders in low‐ and middle‐income countries

Atypical showed no clear difference in diabetes (ADA criteria) (6 weeks) compared with typical antipsychotic medications (low certainty).

1 finding from 1 review

Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
RR 0.5 [0.03, 7.73]
1 study · 93 participants
Low

Melatonin vs placebo

Diabetes · Adults with mental disorders in low‐ and middle‐income countries

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Melatonin vs placebo

Drop‐out Objective · Adults with mental disorders in low‐ and middle‐income countries

Melatonin showed no clear difference in drop‐outs (8 weeks) compared with placebo (low certainty).

1 finding from 1 review

Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
RR 1 [0.38, 2.66]
1 study · 48 participants
Low

Melatonin vs placebo

Fasting blood glucose (mg/dL) · Adults with mental disorders in low‐ and middle‐income countries

1 finding from 1 review

Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 102 participants
Moderate

Melatonin vs placebo

Fasting blood glucose (8 to 12 weeks) (change from baseline data) · Adults with mental disorders in low‐ and middle‐income countries

1 finding from 1 review

Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Moderate

Melatonin vs placebo

Body‐mass index (BMI) · Adults with mental disorders in low‐ and middle‐income countries

1 finding from 1 review

Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 202 participants
Very low