Fungal Infection · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation may leads to lower fungal infection№ of participants: 3266(6 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.23 [0.1, 0.54]
Studies not reported
Low
Chronic lung disease · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in chronic lung disease№ of participants: 2984(5 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 1 [0.89, 1.12]
Studies not reported
Low
Length of hospital stay · prevention of sepsis and necrotizing enterocolitis in preterm infants
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Incidence of NEC within 48 hours after transfusion · preterm infants receiving transfusion
1 finding from 1 review
Incidence of NEC any time after first transfusion · preterm infants receiving transfusion
1 finding from 1 review
Mortality to 44 weeks' postmenstrual age · preterm infants receiving transfusion
1 finding from 1 review
Length of hospital stay · preterm infants receiving transfusion
1 finding from 1 review
Time (days) to achieve exclusive oral feeding · preterm infants receiving transfusion
1 finding from 1 review
Feed intolerance · preterm infants receiving transfusion
1 finding from 1 review
Growth · preterm infants receiving transfusion
1 finding from 1 review
Mortality before hospital discharge · preterm infants
Higher showed no clear difference in mortality to hospital discharge compared with lower amino acid intake (low certainty).
1 finding from 1 review
Neurodevelopmental disability · preterm infants
It is very uncertain whether higher changes neurodevelopmental disability compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Postnatal growth failure (weight < 10th percentile) · preterm infants
It is very uncertain whether higher changes postnatal growth failure at discharge (weight < 10th centile) compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Weight gain · preterm infants
1 finding from 1 review
Head circumference gain (mm/week) · preterm infants
1 finding from 1 review
Retinopathy of prematurity · preterm infants
It is very uncertain whether higher changes retinopathy of prematurity compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Abnormal blood urea nitrogen (various criteria) · preterm infants
Higher leads to higher abnormal blood urea nitrogen (various criteria) compared with lower amino acid intake (high certainty).
1 finding from 1 review
Intervention not reported
Weight gain in first 7 days of study (g/day) · Newborn infants unable to fully breastfeed
1 finding from 1 review
no estimate extracted
522 participants
Low
Intervention not reported
Not breastfeeding at hospital discharge · Newborn infants unable to fully breastfeed
1 finding from 1 review
no estimate extracted
957 participants
Low
Intervention not reported
Not breastfeeding at six months · Newborn infants unable to fully breastfeed
It is very uncertain whether the intervention changes not breastfeeding at six months (very low certainty).
1 finding from 1 review
RR 0.83 [0.72, 0.95]
803 participants
Very low