Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

202 questions · 203 findings · 28 reviews · Haematology

No studies found 46 · 22.7%GRADE not reported 14 · 6.9%Very low 31 · 15.3%Low 68 · 33.5%Moderate 34 · 16.7%High 10 · 4.9%

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with high‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with high‐dose schedule vs standard‐dose strategies

Number of participants with at least 1 clinically significant bleeding event up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with high‐dose schedule showed no clear difference in number of participants with at least 1 clinically significant… compared with standard‐dose schedule (moderate certainty).

1 finding from 1 review

Prophylactic platelet transfusions with high‐dose schedule vs standard‐dose strategies

Number of participants with WHO grade 3 or 4 bleeding up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with high‐dose schedule showed no clear difference in number of participants with WHO grade 3 or 4 bleeding up to 30 days… compared with standard‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with high‐dose schedule vs standard‐dose strategies

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with high‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with standard‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs prophylactic platelet transfusions with standard‐dose schedule

Number of participants with WHO grade 3 or 4 bleeding up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in number of participants with WHO grade 3 or 4 bleeding up to 30 days… compared with prophylactic platelet transfusions with standard‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs prophylactic platelet transfusions with standard‐dose schedule

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with prophylactic platelet transfusions with standard‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of participants with at least 1 clinically significant bleeding event up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in number of participants with at least 1 clinically significant… compared with high‐dose schedule (moderate certainty).

1 finding from 1 review

Intervention not reported

On‐study mortality Death occurring up to 30 days after active study protocol · patients with cancer

The intervention leads to higher on‐study mortality Death occurring up to 30 days after active study… (high certainty).

1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding Number of days with significant bleeding ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Bleeding: Number of days on which a significant bleeding event occurred3 · People with a haematological disorder

Prophylactic platelet transfusion showed no clear difference in bleeding: Number of days on which a significant bleeding event… compared with non prophylactic or therapeutic platelet transfusion (low certainty).

1 finding from 1 review