Findings

What do systematic reviews say?

203 questions · 206 findings · 21 reviews

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No studies found 51 · 24.8%GRADE not reported 11 · 5.3%Very low 59 · 28.6%Low 57 · 27.7%Moderate 19 · 9.2%High 9 · 4.4%

Intervention not reported

"Moderate" benefit At least 30% reduction in pain · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Proportion below 30/100 mm on VAS · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Patient Global Impression of Change much or very much improved · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse event withdrawals · Adults with cancer pain

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Serious adverse events · Adults with cancer pain

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Death · Adults with cancer pain

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Combined paracetamol plus ibuprofen in a single tablet (e.g.… showed no clear difference in proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
2 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
RR 1.29 [0.91, 1.85]
1 study · 170 participants
Moderate

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
Study period (immediate postoperative)
The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
2 studies
GRADE not reported

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Combined paracetamol plus ibuprofen in a single tablet (e.g.… probably leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
6 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
RR 1.77 [1.32, 2.39]
1 study · 170 participants
Moderate

Intervention not reported

Pain free response at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 1 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

At least one AE · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Sustained pain‐free at 24 h · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Serious AE · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Patients not using rescue medication at 8 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
8 hours postdosing · Paracetamol 1000/500 mg/ibuprofen 400/200 mg vs single constituent drugs
RR 1.60 [1.36, 1.88]
2 studies · 467 participants
High

Intervention not reported

Pulmonary Methotrexate pneumonitis · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Moderate

Intervention not reported

Hepatic Liver histology/hepatic enzyme abnormalities2 · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 272 participants
Low

Intervention not reported

Renal Glomerular and tubular injury · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 30 participants
Low