First‐line high‐dose thiazide vs placebo
Withdrawals due to adverse events · adults with primary hypertension
1 finding from 1 review
- no estimate extracted7 studies · 15170 participantsLow
Findings
What do systematic reviews say?
3 questions · 3 findings · 3 reviews
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%
Higher BP target (< 150‐160/95‐105 mmHg) vs lower BP target (< 140/90 mmHg)
Withdrawals due to adverse events · older adults with primary hypertension
Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in withdrawals due to adverse effects compared with lower BP target (< 140/90 mmHg) (low certainty).
1 finding from 1 review
- RR 0.83 [0.58, 1.19]2 studies · 7497 participantsLow
Lower blood pressure targets vs standard blood pressure targets
Withdrawals due to adverse events · cardiovascular disease with high blood pressure
It is very uncertain whether lower blood pressure targets changes participant withdrawals due to adverse effects compared with standard blood pressure targets (very low certainty).
1 finding from 1 review
- Blood pressure targets for the treatment of people with hypertension and cardiovascular disease 2022 · Cochrane Headline outcomes onlyRR 8.16 [2.06, 32.28]3 studies · 801 participantsVery low