What do systematic reviews say?

Cetylpyridinium chloride mouthwash vs Placebo mouthwash

Cetylpyridinium chloride mouthwash led to lower volatile sulphur compounds (VSC), halimeter compared with placebo mouthwash; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD -20.04 [-37.71, -2.37]
  1 study · 47 participants
  GRADE not reported

0.05% chlorhexidine + 0.05% cetylpyridinium chloride + 0.14% zinc lactate mouthrinse vs Placebo mouthwash

Halita mouthwash (chlorhexidine 0.05% + cetylpyridinium chloride… led to lower volatile sulphur compounds (VSC), halimeter compared with placebo mouthwash; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD -188.0 [-308.29, -67.71]
  1 study · 40 participants
  GRADE not reported

Chlorine dioxide + zinc mouthwash vs Placebo mouthwash

Chlorine dioxide + zinc mouthwash led to lower volatile sulphur compounds (VSC), halimeter compared with placebo mouthwash; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  2 weeks
  MD -20.53 [-38.52, -2.54]
  1 study · 41 participants
  GRADE not reported

Cinnamon herbal mouthwash; Nanosil (hydrogen peroxide) mouthwash; Irsha mouthwash vs Water (negative control) and zinc solution (positive control)

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Talebian 2009 (cross-over study) tested cinnamon herbal, Nanosil and Irsha mouthwashes versus water (negative control) and zinc solution (positive control); VSC by halimeter. We could not include the results in the…
  1 study
  GRADE not reported

Protease cysteine + actinidine tablets vs placebo (3 tablets/4 times a day

Protease cysteine + actinidine tablets showed no clear difference in volatile sulphur compounds (VSC), OralChroma compared with placebo tablets; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  1 week
  MD -45.8 [-258.38, 166.78]
  1 study · 14 participants
  GRADE not reported

Lactobacillus beta lactoperoxidase (LPO) tablets vs placebo (3 tablets/4 times a day

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Nakano 2017 (2-arm trial) compared Lactobacillus beta LPO tablets versus placebo tablets (VSC by OralChroma). The trial did not report any usable data and hence could not be included in the analysis.
  1 study
  GRADE not reported

Triclosan mouthwash (with and without alcohol); zinc lactate + chlorhexidine + cetylpyridinium mouthwash vs Placebo mouthwash

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Lopez Jornet 2003 (4-arm RCT) compared triclosan mouthwash with and without alcohol and a zinc lactate + chlorhexidine + cetylpyridinium mouthwash versus placebo mouthwash (VSC by halimeter and OLT). We could not…
  1 study
  GRADE not reported

Toothbrushing + chlorine dioxide mouthwash vs Toothbrushing + tongue cleaning

Toothbrushing + chlorine dioxide mouthwash led to lower volatile sulphur compounds (VSC), sulphide monitor compared with toothbrushing + tongue cleaning; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  4 weeks
  MD -81.87 [-140.12, -23.62]
  1 study · 30 participants
  GRADE not reported

Two-phase oil-water mouthrinse (0.05% cetylpyridinium chloride) vs Control mouthwash

Oil water two-phase mouthwash (with cetylpyridinium chloride) showed no clear difference in volatile sulphur compounds (VSC), sulphide monitor compared with control mouthwash; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  1 week
  MD -11.0 [-25.26, 3.26]
  1 study · 50 participants
  GRADE not reported

Zinc chloride + sodium fluoride dentifrice vs Sodium fluoride (control) toothpaste

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Payne 2011 (cross-over RCT) compared ZnCl + NaF dentifrice versus control NaF dentifrice; VSC by gas chromatography. The trial reported the adjusted mean VSC scores in a graph and hence we could not use the data in the…
  1 study
  GRADE not reported

Triclosan/copolymer-containing fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Niles 1999 (cross-over trial) compared 0.3% triclosan + 2.0% PVM/MA + 0.243% NaF toothpaste versus placebo toothpaste; VSC by gas chromatograph. We could not use the results in the meta-analysis as there was no…
  1 study
  GRADE not reported

Halita mouthrinse vs Perio-plus mouthrinse

Halita mouthrinse showed no clear difference in volatile sulphur compounds (VSC), portable gas chromatograph compared with perio-plus mouthrinse; GRADE not reported.

• Interventions for managing halitosis 2019 · Cochrane All outcomes

  8 days
  MD -25.0 [-64.21, 14.21]
  1 study · 36 participants
  GRADE not reported