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What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 8 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 6 · 75%Moderate 1 · 12.5%High 0 · 0%

Prostanoids vs pentoxifylline

Ulcer healing · people with critical limb ischaemia

It is very uncertain whether prostanoids changes ulcer healing compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs placebo

Ulcer healing · people with critical limb ischaemia

Prostanoids probably leads to higher ulcer healing compared with placebo (moderate certainty).

1 finding from 1 review

Prostanoids vs lumbar sympathectomy

Complete ulcer healing without rest pain or major amputation (per protocol) Clinical assessment · people with critical limb ischaemia due to non‐reconstructable peripheral arterial disease

Prostanoids may leads to higher complete ulcer healing without rest pain or major amputation (per… compared with lumbar sympathectomy (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Ulcer healing · people with critical limb ischaemia

PGE1 showed no clear difference in ulcer healing compared with inositol niacinate (low certainty).

1 finding from 1 review

Iloprost vs PGE1

Ulcer healing · people with critical limb ischaemia

Iloprost showed no clear difference in ulcer healing compared with PGE1 (low certainty).

1 finding from 1 review

Clinprost vs lipo‐PGE1

Ulcer healing · people with critical limb ischaemia

Clinprost showed no clear difference in ulcer healing compared with lipo‐PGE1 (low certainty).

1 finding from 1 review

PGE1 vs ATP

Ulcer healing (complete) · people with critical limb ischaemia

PGE1 showed no clear difference in ulcer healing (complete) compared with ATP (low certainty).

1 finding from 1 review