What do systematic reviews say?

Testosterone vs placebo

It is very uncertain whether testosterone changes treatment withdrawal due to adverse events compared with placebo (very low certainty).

• Testosterone replacement in men with sexual dysfunction 2024 · Cochrane Headline outcomes only
  RR 1.04 [0.58, 1.86]
  2 studies · 122 participants
  Very low
• Testosterone replacement in men with sexual dysfunction 2024 · Cochrane Headline outcomes only
  RR 0.81 [0.56, 1.19]
  12 studies · 2966 participants
  Moderate

Carisbamate vs placebo

It is very uncertain whether carisbamate changes treatment withdrawal due to adverse events compared with placebo (very low certainty).

• Carisbamate add‐on therapy for drug‐resistant focal epilepsy 2021 · Cochrane Headline outcomes only
  RR 1.8 [0.78, 4.17]
  4 studies · 2211 participants
  Very low

Clobazam vs placebo

• Clobazam add‐on therapy for drug‐resistant epilepsy 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 150 participants
  Very low

Shock wave therapy vs placebo

Shock wave therapy showed no clear difference in number of participant withdrawals due to adverse events or treatment… compared with placebo (low certainty).

• Shock wave therapy for rotator cuff disease with or without calcification 2020 · Cochrane Headline outcomes only
  RR 0.75 [0.43, 1.31]
  7 studies · 581 participants
  Low

Calcium channel blockers vs placebo

Calcium channel blockers showed no clear difference in number of withdrawals due to adverse events Number of participants… compared with placebo (low certainty).

• Calcium channel blockers for primary and secondary Raynaud's phenomenon 2017 · Cochrane Headline outcomes only
  RR 1.3 [0.51, 3.33]
  2 studies · 63 participants
  Low