Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Treatment withdrawal · patients with drug‐resistant epilepsy

Flunarizine probably leads to higher treatment withdrawal Number of withdrawals compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists as an add‐on therapy for drug‐resistant epilepsy 2013 · Cochrane Headline outcomes only
RR 7.11 [1.73, 29.3]
4 studies · 247 participants
Moderate

Treatment withdrawal · patients with drug‐resistant epilepsy

Nimodipine showed no clear difference in treatment withdrawal Number of withdrawals compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists as an add‐on therapy for drug‐resistant epilepsy 2013 · Cochrane Headline outcomes only
RR 2.25 [0.25, 20.38]
1 study · 17 participants
Moderate

Number of withdrawals (occurring between 4 and 10 weeks of onset of treatment) · children and adolescents with depression

The intervention showed no clear difference in number of withdrawals (occurring between 4 and 10 weeks of onset of… (low certainty).

1 finding from 1 review

Tricyclic drugs for depression in children and adolescents 2013 · Cochrane Headline outcomes only
OR 1.65 [0.87, 3.14]
8 studies · 462 participants
Low